Artificial vascularized scaffolds for 3D-tissue regeneration — a report of the ArtiVasc 3D Project
Journal Title: International Journal of Bioprinting - Year 2016, Vol 2, Issue 1
Abstract
The aim of this paper is to raise awareness of the ArtiVasc 3D project and its findings. Vascularization is one of the most important and highly challenging issues in the development of soft tissue. It is necessary to supply cells with nutrition within a multilayer tissue, for example in artificial skin. Research on artificial skin is driven by an increasing demand for two main applications. Firstly, for the field of regenerative medicine, the aim is to provide patients with implants or grafts to replace damaged soft tissue after traumatic injuries or ablation surgery. Secondly, another aim is to substitute expensive and ethically disputed pharmaceutical tests on animals by providing artificial vascularized test beds to simulate the effect of pharmaceuticals into the blood through the skin. This paper provides a perspective on ArtiVasc 3D, a major European Commission funded project that explored the development of a full thickness, vascularized artificial skin. The paper provides an overview of the aims and objectives of the project and describes the work packages and partners involved. The most significant results of the project are summarized and a discussion of the overall success and remaining work is given. We also provide the journal papers resulting from the project
Authors and Affiliations
Richard Bibb, Nadine Nottrodt and Arnold Gillner
Rheological study on 3D printability of alginate hydrogel and effect of graphene oxide
In recent years, hydrogels have been used as important biomaterials for 3D printing of three dimensional tissues or organs. The key issue for printing a successful scaffold is the selection of a material with a good prin...
A novel bioactive PEEK/HA composite with controlled 3D interconnected HA network
Polyetheretherketone (PEEK) is a high-performance thermoplastic biomaterial which is currently used in a variety of biomedical orthopaedic applications. It has comparable tensile and compressive strength to cortical bone...
Three-dimensional-printing for microfluidics or the other way around?
As microfluidic devices are designed to tackle more intricate tasks, the architecture of microfluidic devices becomes more complex, and more sophisticated fabrication techniques are in demand. Therefore, it is sensible t...
Concentric bioprinting of alginate-based tubular constructs using multi-nozzle extrusion-based technique
Bioprinting is a layer-by-layer additive fabrication technique for making three-dimensional (3D) tissue and organ constructs using biological products. The capability to fabricate 3D tubular structure in free-form or ver...
New microorganism isolation techniques with emphasis on laser printing
The study of biodiversity, growth, development, and metabolism of cultivated microorganisms is an integral part of modern microbiological, biotechnological, and medical research. Such studies require the development of n...