A new design of an electrospinning apparatus for tissue engineering applications
Journal Title: International Journal of Bioprinting - Year 2017, Vol 3, Issue 2
Abstract
The electrospinning technique is being widely explored in the biomedical field due to its simplicity to produce meshes and its capacity to mimic the micro-nanostructure of the natural extracellular matrix. For skin tissue engineering applications, wound dressings made from electrospun nanofibers present several advantages compared to conventional dressings, such as the promotion of the hemostasis phase, wound exudate absorption, semi-permeability, easy conformability to the wound, functional ability and no scar induction. Despite being a relatively simple technique, electrospinning is strongly influenced by polymer solution characteristics, processing parameters and environmental conditions, which strongly determine the production of fibers and their morphology. However, most electrospinning systems are wrongly designed, presenting a large number of conductive components that compromises the stability of the spinning process. This paper presents a new design of an electrospinning system solving the abovementioned limitations. The system was assessed through the production of polycaprolactone (PCL) and gelatin nanofibers. Different solvents and processing parameters were considered. Results show that the proposed electrospinning system is suitable to produce reproducible and homogeneous electrospun fibers for tissue engineering applications.
Authors and Affiliations
Juliana R. Dias, Cyril dos Santos , João Horta, Pedro Lopes Granja and Paulo Jorge Bártolo
Keywords
Related Articles
- EP ID EP678668
- DOI -
- Views 150
- Downloads 0
3D printing of hydrogel composite systems: Recent advances in technology for tissue engineering
Three-dimensional (3D) printing of hydrogels is now an attractive area of research due to its capability to fabricate intricate, complex and highly customizable scaffold structures that can support cell adhesion and prom...
Hydrolytic Expansion Induces Corrosion Propagation for Increased Fe Biodegradation
Fe is regarded as a promising bone implant material due to inherent degradability and high mechanical strength, but its degradation rate is too slow to match the healing rate of bone. In this work, hydrolytic expansion w...
Functional Approach to Development of Hybrid Technology of Cutting Diamond Carbides
Background: Modern composite materials have a number of advantages in comparison with the traditionally used ones and allow implementing new methods of processing, which makes the finished product cheaper and makes its u...
3D bioprinting technology for regenerative medicine application
Alternative strategies that overcome existing organ transplantation methods are of increasing importance because of ongoing demands and lack of adequate organ donors. Recent improvements in tissue engineering techniques...
Graphene Oxide Induces Ester Bonds Hydrolysis of Poly-l-lactic Acid Scaffold to Accelerate Degradation
Poly-l-lactic acid (PLLA) possesses good biocompatibility and bioabsorbability as scaffold material, while slow degradation rate limits its application in bone tissue engineering. In this study, graphene oxide (GO) was i...