Analysis of brain controllability in patients with major depressive disorder treated with SAINT
Journal Title: Journal of Air Force Medical University - Year 2023, Vol 44, Issue 5
Abstract
Objective Based on the brain network control theory, this study quantitatively reflects the possible response mechanism of Stanford Accelerated Intelligent Neuromodulation Therapy ( SAINT ) by analyzing the brain controllability of differences before and after repetitive transcranial magnetic stimulation treatment and treatment response. Methods This study included 32 patients with major depressive disorder (MDD). Based on the resting functional magnetic resonance imaging of patients before and after treatment, the functional connectivity matrix was established. A linear control model was constructed according to the connectivity matrix to calculate the average controllability ( AC ) and modal controllability (MC) of each brain region. Patients were divided into response group and non-response group according to the decline of Hamilton Depression Rating Scale (HAMD-17) scores after treatment. Two-sample t test was used to compare the differences and changes of controllability between the two groups and before and after treatment. The correlation between pre-treatment controllability and the degree of decline in HAMD-17 scores of brain regions with significant differences in statistical test results was investigated. Results The AC and MC of the right middle temporal gyrus, right inferior parietal lobe, left superior frontal gyrus, bilateral paracentral lobule and bilateral precuneus in MDD patients changed significantly before and after treatment (P < 0. 05). There were significant differences in the AC of the left superior temporal gyrus and the AC and MC of the left posterior superior temporal sulcus between the response group and non-response group before treatment (P < 0. 05). The AC and MC of the left posterior superior temporal sulcus and the AC of the left superior temporal gyrus were significantly negatively correlated with the percentage of decline in HAMD-17 scores (P < 0. 05). Conclusion The neural response mechanism of SAINT therapy may be related to measurement of AC and MC in the right middle temporal gyrus, right inferior parietal lobe, left superior frontal gyrus, bilateral paracentral lobule and bilateral precuneus in MDD patients. In addition, the therapeutic effect of SAINT may be correlated with the degree of AC and MC in the left posterior superior temporal sulcus and the AC of the left superior temporal gyrus before treatment.
Authors and Affiliations
WANG Jia, ZHAI Wensheng, LU Hongbing, LIANG Qian, WANG Wei, LI Baojuan
Keywords
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