Genome-wide association analysis of POCD susceptibility in elderly patients after cardiac surgery with cardiopulmonary bypass
Journal Title: Journal of Air Force Medical University - Year 2023, Vol 44, Issue 4
Abstract
Objective To screen the susceptibility gene loci for cognitive dysfunction after cardiac surgery with cardiopulmonary bypass (CPB) in elderly patients. Methods A total of 120 patients scheduled for cardiac surgery with CPB were selected, 5 mL of blood was collected before anesthesia induction, cognitive function was tested 1 d before surgery and 7 d after surgery, and postoperative cognitive dysfunction (POCD) was determined by Mini-Mental State Examination. Thirty-six patients with POCD and 36 patients without POCD were randomly selected, and genome-wide association study was used to screen the susceptibility genes for POCD after cardiac surgery with CPB. Results A total of 370 384 single nucleotide polymorphism (SNP) loci were identified by high-throughput sequencing in patients with POCD and those without POCD, among which 104 SNP loci ( P < 0. 05) were associated with the occurrence of POCD after cardiac surgery with CPB. These SNP loci were mainly concentrated on chromosomes 1, 2, 7, 11, 13, and 15, with intron mutations and upstream gene mutations as their main mutation types. Bioinformatics analysis showed that the biological processes and functions involved mainly included ion homeostasis and hormone synthesis and secretion. Conclusion There are differences in susceptibility genes between POCD patients and the normal population.
Authors and Affiliations
GUO Jingzhi, DENG Jiao, HUANG Xinwei, ZHAO Guangchao, HOU Wugang
Keywords
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