Anti-mutagenic protection of Quercus infectoria galls against 2-Aminoanthracene induced genotoxicity in mice bone marrow
Journal Title: World Journal of Pharmaceutical Sciences - Year 2017, Vol 5, Issue 5
Abstract
The present study evaluated the mutagenic and antimutagenic protective effects of Quercus infectoria galls (QIG) against genotoxicity induced by 2-Aminoanthracene (2AA). Mice bone marrow mitotic index, chromosomal aberration, and micronucleus assay were employed to measure the genotoxicity, respectively. Mice were treated with aqueous extract of QIG (2, 5 and 7 gm/kg body weight) for 7 days. Without the dose of 2AA, no mutagenic effects were observed in bone marrow samples of the mice. QIG extract by itself did not show any harmful effects but it significantly improve mitotic activity in bone marrow cells at the dose 2 gm/kg body weight .Pre-, post- and simultaneous treatments with 2AA were carried out in vivo. It was observed that the dose 2gm/kg of QIG administrated 7 days before injection of 2AA (at the dose of 750 mg/kg) caused the most statistically significant decrease of 2AA induced chromosome aberration , micronuclei frequency and stimulate cell proliferation in bone marrow cells of mice as compared to 2AA group. Showing antimutagenic protective effects on 2AA induced mutagenicity in mice. Thus, it can be concluded from the study that aqueous extract of QIG exhibited no clastogenic effects but only possessing antimutagenic effects. This antimutagenic activity is an induction of its medicinal relevance.
Authors and Affiliations
Arafat Mohammed Bin Mohammed
Keywords
Related Articles
- EP ID EP330230
- DOI -
- Views 107
- Downloads 0
Assessment of knowledge and roles of patent medicine vendors in the implementation of national malaria treatment policy in Nigeria
Introduction: Patent Medicine Vendors (PMVs) are the first source of care for both children and adults seeking malaria treatment. This study sought to investigate the knowledge and roles of the PMVs in the implementation...
Effect of Ginkgo Biloba and Commiphora Opobalsamum Extracts on Liver Fibrosis and Kidney Injury Induced By Carbon Tetra Chloride in Experimental Models
Ginkgo biloba and Commiphora opobalsamum are herbal medicines ,which have important effects on health. The present study was designed to explore the ameliorative effect of Ginkgo biloba and Commiphora opobalsamum on live...
Method development and validation for simultaneous estimation of telmisartan and amlodipine by RP-HPLC
A novel, precise, accurate, rapid and effective isocratic RP-HPLC method was developed, optimized and validated for the estimation of Telimsartan (TEL) and Amlodipine (AML) in pharmaceutical dosage forms (tablet). The dr...
Knowledge, attitude and practice of physiology teaching among medical practitioners of Northern India
The aim of the present study is to assess knowledge, attitude and practices of physiology teaching among medical practitioners of northern India. The present study was carried out in Northern India with 264 medical pract...
Advancement in Dengue Treatment: A review
This review describes and commentates on recent advances in the understanding of dengue diagnosis and immunity, plus clinical research on vaccines and therapeutics. We expand specifically on the role of the dermis in den...