Anti-mutagenic protection of Quercus infectoria galls against 2-Aminoanthracene induced genotoxicity in mice bone marrow
Journal Title: World Journal of Pharmaceutical Sciences - Year 2017, Vol 5, Issue 5
Abstract
The present study evaluated the mutagenic and antimutagenic protective effects of Quercus infectoria galls (QIG) against genotoxicity induced by 2-Aminoanthracene (2AA). Mice bone marrow mitotic index, chromosomal aberration, and micronucleus assay were employed to measure the genotoxicity, respectively. Mice were treated with aqueous extract of QIG (2, 5 and 7 gm/kg body weight) for 7 days. Without the dose of 2AA, no mutagenic effects were observed in bone marrow samples of the mice. QIG extract by itself did not show any harmful effects but it significantly improve mitotic activity in bone marrow cells at the dose 2 gm/kg body weight .Pre-, post- and simultaneous treatments with 2AA were carried out in vivo. It was observed that the dose 2gm/kg of QIG administrated 7 days before injection of 2AA (at the dose of 750 mg/kg) caused the most statistically significant decrease of 2AA induced chromosome aberration , micronuclei frequency and stimulate cell proliferation in bone marrow cells of mice as compared to 2AA group. Showing antimutagenic protective effects on 2AA induced mutagenicity in mice. Thus, it can be concluded from the study that aqueous extract of QIG exhibited no clastogenic effects but only possessing antimutagenic effects. This antimutagenic activity is an induction of its medicinal relevance.
Authors and Affiliations
Arafat Mohammed Bin Mohammed
Keywords
Related Articles
- EP ID EP330230
- DOI -
- Views 82
- Downloads 0
Chemical Constituents from Senecio bombayensis
Plants belonging to the family Asteraceae and the genus Senecio were reported to contain varied compounds with medicinal importance. Senecio bombayensis, a species of Senecio was not studied chemically and hence the auth...
Antiasthmatic Effect of Saxagliptin on Ovalbumin-Induced Allergic Asthma in Mice
In the current study, the protective activity of saxagliptin (SAX) on ovalbumin (OVA)-induced allergic asthma in mice was evaluated. Methods: Mice with OVA-induced allergic asthma were orally administered SAX at a dose o...
A Pilot Study on the Relationship of the Cytoskeleton Components with Normal Cellular Functions and Injuries in Malignant and Neuro-Degenerative Multi-Factor Disorders, Using Biological Systems with Rat, Mouse and Human Origin
The main goal of the current study was directed to evaluation of technologies for precise identification of changes in the cellular components and compartments, composed of bio-molecules and intra-molecular structures wa...
In-vitro pharmacological applications of pigment producing halophilic microorganism from the marine region of India
In the present study, two pigment producing promising strains were identified and characterized based on the biochemical properties from the halophilic environment. Based on the biochemical and physiological characterist...
GCMS and FTIR analysis on the methanolic extract of red Vitis Vinifera seed
Vitis Vinifera seed is a member of vitaceae family which contains high phenolic procyanidins, Gallic acid, Catechin, Anthocyanin, Vitamin E, linoleic acid and flavonoids. Our present work aimed to identify the possible p...