Anti-Nociceptive and Anti-Inflammatory Activities of the Hydroethanolic Extract of the Leaf of Clerodendrum polycephalum (Lamiaceae)
Journal Title: SSR Institute of International Journal of Life Sciences (SSR-IIJLS) - Year 2018, Vol 4, Issue 4
Abstract
Background- The mainstay of the treatment of pain and inflammation are opioids, steroids, non-steroidal, and anti-inflammatory drugs. Though, they are effective but readily available with negative and unpleasant effects, most worst things are hepatotoxicity and nephrotoxicity, thus there is big need for safer and effective therapy in the management of pain and inflammation. Methods- In present study HeCP (100, 200 or 400 mg/kg, p.o.) given to mice and 1 h before administered with acetic acid (0.6% v/v, i.p.), formalin (1%v/v, intraplantar) or capsaicin (1% w/v, intraplantar) for observing nociceptive behavior in mice while carrageenan (1% w/v in saline, intraplantar) or cotton pellet (20 mg implanted into both groin) to induce acute or chronic inflammation in rats. Results- HeCP (100 – 400 mg/kg, p.o.) reduced mean writhes number, duration of paw licking or biting in the acetic acid, formalin and capsaicin models, respectively, in mice. However, the initial treatment of mice with L-NNA (neuronal nitric oxide synthase inhibitor), naloxone (opioid receptor antagonist), or glibenclamide (ATP-sensitive K+ channel blocker) prevented HeCP induced anti-nociception in mice. In contrast, the initial treatment of mice with, sulpiride (dopamine D2-receptor antagonist) failed to reverse HeCP-induced antinociception. In the aspect of anti-inflammatory activity, HeCP caused significantly but not dose dependent inhibition of edema development in carrageenan-induced inflammation and cotton pellet-induced granuloma formation in rats. Conclusion- Findings from this work indicated that the hydroethanolic leaf extract of C. polycephalum had anti-nociceptive and anti-inflammatory possiblity due to its polyphenolic constituents.
Authors and Affiliations
Amole OO, Ishola IO, Akinyede AA, Adewale MT
Keywords
Related Articles
- EP ID EP670994
- DOI 10.21276/ijlssr.2018.4.4.3
- Views 102
- Downloads 0
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