Anti Trypanosomal Activity of Crude Extracts Of Endophytic Fungi (Acremonium Sp.) Isolated From Ocimum Gratisimum Leaf.
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2018, Vol 13, Issue 6
Abstract
Trypanosomiasis is a parasitic disease that affects both humans and animals. It is caused by the parasitic protozoan, trypanosome,. The development of a vaccine for the treatment of the disease is becoming increasingly complicated due to the problem of antigenic variation, thus the reliance on chemotherapeutic agents to control the disease.Drugs derived from natural sources play an important role in the avoidance and treatment of human diseases.Recent studies have shown a variety of health properties of endophytic fungal extract. The ethylaceted and the methanolic extraction were carried out. The bioactive fungal extract was tested invitro on Trypanosoma brucei brucei (federe strain). The in vitro assessment of Acremonium sp extract show graded trypanocidal activity at different concentrations with LC50of0.204, as indicated in the table of percentile. It also shows that as the concentration Increase the mortality also increases.
Authors and Affiliations
Malala A. U. , Dayyiba A. M. , Machina I. B
Keywords
Related Articles
- EP ID EP415716
- DOI 10.9790/3008-1306013437.
- Views 76
- Downloads 0
A Study on the Correlation between Infection with Helicobacter Pylori and Hepatic Encephalopathy in Patients with Chronic Liver Disease
Background: Hepatic encephalopathy is a complex neuropsychiatric syndrome occurring in patients with severe hepatic insufficiency. A multitude of factors and pathogenic processes appear to be operative, with the accumula...
Time to Redefine Physics
Einstein got ZERO Marks on the assumption of Space Time Gravity Theory calling Space time ripples on 6 June 1907 . But Noble Prize has been given on same illusive theory in 1993 and 2017 . Pl read papers published condem...
“Antimicrobial activity of rhizospheric bacteria of Curcuma longa (Turmeric) producing metabolites against human pathogens”
The present study was carried out to explore the production of antibiotics from soil microbes of medicinal Plant Curcuma longa (Turmeric). Soil samples of the Curcuma longa rhizosphere regions were collected from the dif...
Ultrastructural Study of two Parasites Infecting Domesticated Turkey Meleagris Gallopavo Linnaeus, 1758 (Galliformes: Meleagridinae) Qena, Egypt
This work provides a detailed systematic morphology by optic and Scanning electron microscopy of two parasites Raillietina echinobothriida Megnin, 1880 and Spirora meleagaris n. sp. infecting domesticated turkey. The pre...
Genetic Variation in Progeny Performance Traits in Soapnut (Sapindus Mukorossi Gaertn.) of Himachal Pradesh.
Evaluation in Progeny performance traits was carried out among different twenty four seed sources and in two D.B.H. classes. Progeny performance traits of soapnut seedlings were recorded at intervals, of 3 months and 6 m...