The Possible Ameliorative Role of Anethum Graveolens Against Tramadol-Induced Testicular Damage in Male Albino Rat
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2018, Vol 13, Issue 1
Abstract
Nowadays, tramadol hydrochloride (TM) is becoming abused more popular among teens in most countries worldwide; especially between males. The aim of present study was to investigate the biochemical and histopathological profiles of subchronic model of TM toxicity on testicular functions. Experimental study, Rats was divided into three groups. Group one received saline, group two received oral doses of TM (100 mg / kg b.w), group three received anethum graveolens (AG) two hours before tramadol (NG+TM). The experiment lasted for a one month. The results showed that a significantly decrease in serum testosterone, luteinizing hormone (LH), follicle stimulating hormone (FSH), and cortisol, but elevated prolactin (PRL) and estradiol (E2) in male albino rats after 30 days of TM group. In the same concern 8-hydroxydeoxyguanosine (8-OHdG), protein carbonyl (PC) and MDA levels, as indicators of oxidative stress, were significantly (P<0.05) increased in group TM in comparing with control group. Moreover, TM group displayed an increase of tumor necrosis factor-α (TNF-α), and nitric oxide (NO) in the testes tissues and decreased in glutathione-S-transferase (GST) activity and glutathione (GSH). Also, showed a significant increase in acid phosphatase, N-acetyl-β-Dglucosaminidase and β-galactosidase in testes rat, meanwhile Anethum graveolens (AG) administration caused significantly ameliorative in all parameters in comparing to TM group.
Authors and Affiliations
1 Fawzy M. lashin, Ibrahim M Abo laila
Keywords
Related Articles
- EP ID EP393205
- DOI 10.9790/3008-1301018290
- Views 83
- Downloads 0
Antimicrobial Activity of Bauhinia Purpurea (L) by Minimum Inhibitory Concentration (MIC) Method
MIC methods are widely used in the comparative testing of new agents, or when a more accurate result is required for clinical management. As there are no CLSI (formerly NCCLS) recommendations for the determination of MIC...
A “Rocambolesque” Strategy To Combat Definitively Lichen Simplex Chronicus In Black Skinned People.
Scope of our study is to treat Lichen simplex chronicus that is very evident in white people so that all Researchers of the Occidental World focus their attention to this concern, forgetting to observe that the same Lich...
Analysis of drug dispensing by risk management method at three teaching hospitals in Abidjan, Cote d’Ivoire
Introduction: In hospitals, an optimum drug dispensing (DD) is involved in the quality of health services and the prevention of medication errors. This study aims to describe the features of hospital DD in Cote d’Ivoire...
The effect of excipients on captopril release from preparations disintegrating in the oral cavity (ODT)
Captopril is often used to treat hypertension in newborns, infants and the elderly. Orodispersible tablets (ODT) may be a beneficial solution when given to this group of patients. For this purpose, tablets were made and...
Findings of Gas chromatography - Mass Spectrometry (GCMA) Analysis of Eclipta Alba Plant Root
Background: Eclipta alba L. Hassk. (Asteraceae), commonly known as Bhringaraja (Sanskrit), Maka (Marathi) and Bhangra (Hindi) has been reported to show protective effect on experimental liver damage in rats and mice. Thi...