The Possible Ameliorative Role of Anethum Graveolens Against Tramadol-Induced Testicular Damage in Male Albino Rat
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2018, Vol 13, Issue 1
Abstract
Nowadays, tramadol hydrochloride (TM) is becoming abused more popular among teens in most countries worldwide; especially between males. The aim of present study was to investigate the biochemical and histopathological profiles of subchronic model of TM toxicity on testicular functions. Experimental study, Rats was divided into three groups. Group one received saline, group two received oral doses of TM (100 mg / kg b.w), group three received anethum graveolens (AG) two hours before tramadol (NG+TM). The experiment lasted for a one month. The results showed that a significantly decrease in serum testosterone, luteinizing hormone (LH), follicle stimulating hormone (FSH), and cortisol, but elevated prolactin (PRL) and estradiol (E2) in male albino rats after 30 days of TM group. In the same concern 8-hydroxydeoxyguanosine (8-OHdG), protein carbonyl (PC) and MDA levels, as indicators of oxidative stress, were significantly (P<0.05) increased in group TM in comparing with control group. Moreover, TM group displayed an increase of tumor necrosis factor-α (TNF-α), and nitric oxide (NO) in the testes tissues and decreased in glutathione-S-transferase (GST) activity and glutathione (GSH). Also, showed a significant increase in acid phosphatase, N-acetyl-β-Dglucosaminidase and β-galactosidase in testes rat, meanwhile Anethum graveolens (AG) administration caused significantly ameliorative in all parameters in comparing to TM group.
Authors and Affiliations
1 Fawzy M. lashin, Ibrahim M Abo laila
Keywords
Related Articles
- EP ID EP393205
- DOI 10.9790/3008-1301018290
- Views 105
- Downloads 0
Influence of the Genetic Profile on the Therapeutic Conduct of Invasive Breast Ductal Carcinoma: A Systematic Review of Literature
Breast cancer is the most frequently diagnosed type in the world and the leading cause of cancerrelated death among women. Its central component of treatment is full knowledge of the extent of disease and biological char...
Red Sanders in Rayalaseema Region of Andhra Pradesh: Importance to Commercial & Medicinal Value
.
Histological and Biochemical Study of Different Doses of Tamoxifen Drug on Liver Of Albino Male Rat
Tamoxifen is an effective anticancer drug. It's a hormonal treatment against estrogen which is necessary for the growth of cancer cells. This study was conducted to evaluate the negative effects of Tamoxifen on some phys...
Phenthoate 50% EC Toxicity and Its Impact on Aminotransferases of Freshwater Fish Catla (Gibelion catla)
The toxicity of commercial grade Phenthoate 50% EC. to the freshwater fish Catla (Gibelion catla) using static system, LC50 values were determined as 14.2, 13.0, 12.0 and 7.0 ppm respectively. The fish were exposed to Le...
Validation of Analytical Methods for Determination of Methamphetamine Using Fourier Transform Infrared (FTIR) Spectroscopy
Validation of analytical methods for determination of methamphetamine using Fourier Transform Infrared (FTIR) Spectroscopy has been done. Parameter validation method are the repeatability of the system (precision), accur...