Influence of the Genetic Profile on the Therapeutic Conduct of Invasive Breast Ductal Carcinoma: A Systematic Review of Literature
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2018, Vol 13, Issue 4
Abstract
Breast cancer is the most frequently diagnosed type in the world and the leading cause of cancerrelated death among women. Its central component of treatment is full knowledge of the extent of disease and biological characteristics, where the use of genetic profile has contributed to tumor characterization and therapeutic targeting. Then, the objective this study was evaluated the use of the genetic profile of invasive ductal carcinoma of the female breast and it’s obtained scores. To verify its use or not for directing the treatment of breast cancer in surgery, radiotherapy and chemotherapy. A search was performed on the PUBMED and SCOPUS databases, with the following descriptors and their synonyms: breast neoplasm, gene expression profile, genetic test, radiotherapy, surgery, chemotherapy, recurrence, survival and prognostic marker, as well as their correspondents in English.We selected nine articles published in international journals. Results: The use of genetic profile is related to recurrence scores for chemotherapy treatment and evidence of its use for applicability in chemotherapy and surgical treatment. The definition of therapy in the treatment of breast cancer in the early stages has been widely discussed in the scientific community regarding clinical, pathological and immunohistochemical criteria. Genetic susceptibility studies may provide useful information to the clinical staff in deciding the most appropriate therapeutic approach in specific cases. There is a need for further studies in the application of molecular profiles for personalized treatment, especially for patients with specific genetic mutations
Authors and Affiliations
André Luiz Freitas De Lima Filho, Simone Krause Ferrão, Carine Tasso, Joyce Bonazzoni, Vanessa Zafaneli Bergamo, Adelina Mezzari, Renata Pereira Limberger, Luciane Noal Calil
Keywords
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- EP ID EP395499
- DOI 10.9790/3008-1304021722
- Views 71
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