ANTIOXIDANT AND HEPATOPROTECTIVE ACTIVITY OF METHANOLIC EXTRACT OF HYGROPHILA SCHULLI LEAVES
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 7
Abstract
The objective of this study was to investigate the antioxidant effects of methanolic extract of leaves of Hygrophila schulli against paracetamol induced liver damage. The material was dried in shade; they were powdered and extracted with methanol. The antioxidant effects of the methanol extract was assessed in paracetamol induced hepatotoxic rats. Alteration in the levels of antioxidant markers of hepatic damage like LPO, SOD, CAT, GPx and GST were tested in both paracetamol treated and untreated groups. Treatment of methanolic extract of Hygrophila schulli leaves (500 mg/kg) has brought back the altered levels of antioxidant markers to the near normal levels in the dose dependent manner. Our finding suggested that Hygrophila schulli methanol leaf extract possessed Antioxidant activity.
Authors and Affiliations
Sumathi A. , Vijayakumar S.
Keywords
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