Assessment of glycemic control, glucose variability, and hypoglycemic incidence using insulin degludec in children and adolescent with type I diabetes
Journal Title: Medpulse International Journal of Pediatrics - Year 2018, Vol 7, Issue 1
Abstract
Objective: The objective of this study is to study the most recent evidence on glucose variability using insulin degludec comparing it with insulin Glargine in children and adolescents with C-Pepde negative type I Diabetes and to assess the effect of using insulin Deglude on Glucose variability, Hypo and hyperglycemic events, safety and tolerability Design: The current study investigated once-daily insulin degludec versus insulin Glargine, both in combination with bolus insulin aspart in a 36week trial using SMBG and CGM, in children and adolescents with C-Peptide negative Type1DM. Setting Urban Superspeciality hospital and medical college AIIMS (American international institute of medical sciences Udaipur Rajasthan Participants 33 children and adolescents (between 10-18 yrs age) with c-peptide negative i.e less than 0.3 ng/mL type 1 diabetes Main outcome The levels of Fasting Blood Glucose (FBG’s) HbA1c mean value, SDs, blood glucose variability that is blood glucose ≥ 180 and BG < 70 all decreased in Insulin Degludec group. Results: The levels of Fasting Blood Glucose (FBG’s) HbA1c mean value, SDs, blood glucose variability that is blood glucose ≥ 180 and BG < 70 all decreased in Insulin Degludec group. HbA1c reduction was 1.58 in insulin degludec group while HbA1c reduction was 0.92 in insulin glargine group. Fasting blood glucose (FBG’s) was 108 ± 10 mg/dl in insulin degludec group while it was 138 ± 26 mg/dl in insulin glargine patients Conclusions: It is concluded that insulin degludec suppressed daily fluctuations of FBG and PPBG, suppressed the occurrence frequency of hyperglycemia and hypoglycemia, glucose variability and exerted more steady hypoglycemic actions, well tolerated and safe in children and adolescents.
Authors and Affiliations
Akhilesh Bisaria, R E Bhingare, N Pipliwal, Sarvesh Bisaria
Keywords
Related Articles
- EP ID EP414042
- DOI -
- Views 194
- Downloads 0
Anxiety and depression in parents caring for a child with chronic disease: A cross sectional comparative study
Background: Caring for a child with a chronic illness can be stressful for the parent which can in turn affect the parent child interaction and treatment adherence. We aimed to screen parents who are caregivers of childr...
Breast feeding practices, knowledge and attitude among mothers- An institutional study
Breast feeding is the ideal food which gives all the essential nutrients need for healthy development for new born and infants and has several benefits for both the infants and mothers. Breast milk is readily available,...
Epidemiological profile of hypertension and various risk factors in adolescents
Background: Primary hypertension hasbeen now shown to be most common among adolescents, and usuallypresents as stage I hypertension along with a positive family history. Secondary hypertension has various systemic causes...
Relationship between maternal haemoglobin and neonatal birth weight
Background: The birth weight of an infant is the most important determinant of its chance of survival health growth and development. The prevalence of low birth weight (LBW) is higher in Asia than elsewhere. Low birth we...
A study of various risk factors associated with development of severe respiratory distress in the new born at tertiary health care center
Background: Neonatal respiratory distress occurs in infants whose lungs have not yet fully developed. The earlier a baby is born, the less developed the lungs are and the higher the chance of neonatal respiratory distres...