ASSESSMENT OF PHYSICOCHEMICAL PROPERTIES OF EIGHT BRANDS OF ALPHA METHYLDOPA TABLETS MARKETED IN ZARIA, KADUNA STATE,NIGERIA
Journal Title: Mintage journal of pharmaceutical and medical sciences - Year 2016, Vol 5, Issue 1
Abstract
Objective: The aim of this research is to determine the quality and uniformity of brands of α-Methyldopa 250 mg tablets marketed in Zaria, Kaduna State, Nigeria. Methods: Eight (8) brands of α-Methyldopa 250 mg tablets labelled as samples A, B, C, D, E, F, G and H were used to ascertain the level of uniformity within each batch and from brand to brand using the quality control tests such as identification test, uniformity of weight test, friability test (FR), crushing strength test (CS), disintegration time test (DT), dissolution test and test uniformity of active content. Results: All the brands of the methyldopa tablets used passed the BP standards for identification test, uniformity of weight, thickness, diameter and friability test but failed CS test except sample A and G, which showed CS within the range of 4-8 Kgf. All the brands except sample G complied with the BP, 2009 specification of DT. Also, all the brands except sample G passed the uniformity of active content test (Assay) specified by the BP, 1980 with little significant difference; A=95.96 %, B=97.98 %, C=102.02 %, D=96.40 %, E=100.89 %, F= 102.92 %, G=46.52 %, and H=97.08 %. Similarly, all the brands complied with the dissolution rate test stipulated by the Indian Pharmacopeia 4th Edition except sample G with a significant low dissolution profile after 60 minutes; 95.96 %, 98.01 %, 101.65 %, 95.68 %, 100.69 %, 102.02 %, 42.26 % and 97.16 % for the sample A, B, C, D, E, F, G, and H respectively. Conclusion: There is a considerable degree of uniformity among the brands examined except sample G.
Authors and Affiliations
Gideon o. Okpanachi, Ifeanyi v. Emenike, Hassan musa, Yusuf mohammed, mahmud s. Gwarzo
Keywords
Related Articles
- EP ID EP438108
- DOI -
- Views 139
- Downloads 0
CENTELLA ASIATICA L.: A CONCISE DRUG REVIEW WITH PROBABLE CLINICAL USES
Centella asiatica L. is widely used as a medicinal herbs and alternative medicine in treating numerous kinds of diseases since prehistoric times. It is a perennial, creeper, faintly aromatic and a valuable medicinal herb...
COMPARISON OF THE JOB BURNOUT IN HOSPITAL EMERGENCY PERSONNEL AND PRE-HOSPITAL EMERGENCY PERSONNEL OF SHIRAZ
Background: One of the biggest concerns of the healthcare organization is the emergency staff of the emergency staff facing the crisis. Purpose: The purpose of this study was to compare the burnout of operational personn...
BIOSYNTHESIS OF AgNPs WITH THREE WIDESPREAD LOAM FUNGI VIA ASPERGILLUS FUMIGATUS, FUSARIUM SPP. RHIZOPUS SPP
Objectives: Biosynthesis of silver nanoparticles using fungi Aspergillus fumigatus, Fusarium spp. and Rhizopus spp. for the potential synthesis of metal nanoparticles. Methods: The standard techniques have been followe...
ANTISOLAR AND ANTIOXIDANT ACTIVITY OF FRESH BERRIES OF CESTRUM NOCTURNUM
Aim: This paper evaluates the UV absorption ability of berries from Cestrum nocturnum (Solanaceae) as an anti-solar agent and antioxidant activity. Material and Methods: premature and mature berries with different concen...
IN SILICO STUDIES ON Tithonia Diversifolia DERIVED PHYTOCHEMICALS AS POTENT INHIBITOR OF CYCLOOXYGENASE
Objectives: Prostaglandins released by the activity of the bifunctional enzyme, cyclooxygenase (COX) are involved in physiological functions such as protection of the stomach mucosa, aggregation of platelets and regulati...