Association between systemic immune-inflammation index and disability among Polish ischemic stroke patients receiving intravenous thrombolysis: a single-center, prospective cohort study
Journal Title: International Neuroscience Conference (NEURO-2023) - Year 2023, Vol 4, Issue 1
Abstract
The inflammatory response plays a central role in the pathophysiology of ischemic stroke. One of the newest laboratory markers with potential for predicting the outcomes of ischemic stroke patients is the systemic immune-inflammation index (SII), but knowledge of its actual utility is limited. This prospective cohort study aimed to assess the association of SII with disability in ischemic stroke patients.The study included 51 patients who were diagnosed with ischemic stroke and qualified for intravenous thrombolysis. Before therapy, upon admission to the hospital, each patient underwent complete blood count, based on which the SII was calculated as the product of the count of platelets (P) and the count of neutrophils (N), divided by the count of lymphocytes (L); SII = P x N/L. The disability of patients was assessed using the modified Rankin Scale (mRS) on days 7, 30, and 90 after admission to the hospital. Patients were divided into two subgroups depending on mRS: those who were independent (mRS = 0-1) and those who showed any degree of dependence (mRS = 2-5). Nineteen women and 32 men with a median age of 70 years who underwent intravenous thrombolysis for ischemic stroke were included in the study. On day 7 after hospital admission, mRS was assessed in all patients, and on days 30 and 90, in 49 and 40 patients, respectively. Statistical analysis by the Mann-Whitney U test demonstrated no significant differences in SII between patients with mRS = 0-1 and patients with mRS = 2-5 at each time point (median SII = 531.3 vs. 469.8, p = 0.92; median SII = 509.3 vs. 535.9, p = 0.68; median SII = 473.8 vs. 443.3, p = 0.85, on days 7, 30 and 90, respectively). The area under the receiver operating characteristic curve (AUC-ROC) confirmed no relationship between SII and mRS on days 7, 30, and 90 after the patient’s admission to the hospital. In conclusion, our study found no relationship between SII and mRS in ischemic stroke patients who have undergone intravenous thrombolysis. Further research is needed, expanding the size of the study group and the diversity of ischemic stroke therapy.
Authors and Affiliations
Artur Słomka, Iga Kwiatkowska, Agata Bloch, Magdalena Sury, Urszula Rosińska, Małgorzata Wiszniewska, Ewa Żekanowska
Keywords
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