The effect of GLP-1 agonist (Liraglutide) on the neurological scores, Blood –brain barrier, brain water content and vestibulomotor function after severe traumatic brain injury in male rat: the role of IL-1β and IL-10
Journal Title: International Neuroscience Conference (NEURO-2023) - Year 2023, Vol 4, Issue 1
Abstract
Introduction: Liraglutide is a long-acting analogue of Glucagon-like peptide-1 (GLP-1) that is primarily used in type 2 diabetes and obesity. It stimulates GLP-1 receptors and insulin secretion, and is dose-dependent and plasma glucose-dependent, reducing blood glucose and resulting in a low risk of hypoglycaemia. It also has neuroprotective and anti-apoptotic effects and can be used to treat diseases such as Alzheimer's, Parkinson's and dementia, but the mechanism of action of this drug is not fully understood. Therefore, in this study we investigated the neuroprotective effects of Liraglutide after induction of brain trauma in male rats. Materials and methods: Rats received different doses of Liraglutide (0.2, 0.4, 0.8 mg / kg) intraperitoneally 30 minutes after induction of brain injury by the Marmarou method. VCS of animals were recorded before trauma (pre), trauma day (D0), 24 hours later (D1), 48 hours (D2) and 72 hours (D3) after TBI induction. Vestibulomotor tests were evaluated by Beam Walk (BW) and Beam Balance (BB) tests in similar fashion. To determine permeability of Blood-Brain Barrier (BBB) and brain edema 24 hours after TBI induction, Evans-Blue dye and Wet-Dry methods were employed respectively. Cerebrospinal fluid (CSF) was collected 24 hours after TBI induction to evaluate the levels of a proinflammatory cytokine (IL1β) and anti-inflammatory cytokine (IL-10). Results: Results have shown that traumatic brain injury can lead to brain edema, destruction of the blood-brain barrier, changes in neurological and equilibrium animal scores, dramatically increased IL-1β and decreased IL-10 but administration of liraglutide at doses of 0.2 mg / kg and 0.4 mg / kg were able to reduce these abnormalities compared to the control group, which was more significant at the 0.4 mg / kg dose. Liraglutide administration at a dose of 0.4 mg / kg in the first 24 hours after TBI decreased IL-1β levels and increased IL-10 levels. Conclusion: In the present study, it is understood that single dose administration of Liraglutide at doses of 0.2 and 0.4 mg / kg after induction of brain trauma has positive effects on traumatic brain injury, which may reduce neuroinflammation. These beneficial effects were more pronounced at a dose of 0.4 mg / kg.
Authors and Affiliations
Vahid Asgarifard, Farid Askarifard*, Fariba Rajabi, Ali Siahposht-khachaki
Keywords
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