Beneficial effects of levetiracetam in streptozotocin-induced rat model of Alzheimer’s disease
Journal Title: International Neuroscience Conference (NEURO-2023) - Year 2023, Vol 4, Issue 1
Abstract
Alzheimer’s disease (AD) is the most common neurodegenerative disorder among the elderly. In the light of increasing AD prevalence and lack of effective treatment, new strategies to prevent or reverse this condition are needed. Levetiracetam (LEV) is a newer antiepileptic drug that is commonly used to treat the certain types of seizures. Researches indicated that LEV has several other pharmacological activities, including improvement of cognitive function. In this study, the recovery effects of chronic (28 days) administration of LEV (50, 100 and 150 mg/kg, ip) on cognitive deficits caused by the intracerebroventricular (icv) injection of streptozotocin (STZ), as a model for sporadic AD, were evaluated in rats. We also considered the protective effects of LEV against hippocampal cell loss, oxidative damage, acetylcholinesterase (AChE) activity, neuroinflammation, and tauopathy caused by STZ. LEV (100 and 150 mg/kg) significantly attenuated the STZ-induced learning and memory impairments in the passive avoidance and Morris water maze (MWM) tasks. In addition, LEV suppressed STZ-induced hippocampal neuronal loss, while restored alterations in the redox status (lipid peroxides and glutathione), AChE activity, proinflammatory cytokines (IL-1β, IL-6, TNF-α) and hyperphosphorylation of tau linked to STZ administration. In conclusion, our study demonstrated that LEV alleviated hippocampal cell death and memory deficits in STZ-AD rats, through mitigating of oxidative damage, the increased expressions of proinflammatory cytokines and tau hyperphosphorylation.
Authors and Affiliations
Hamid R. Sadeghnia*, Mohaddeseh Sadat Alavi, Sahar Fanoudi, Mahmoud Hosseini
Keywords
Related Articles
- EP ID EP747387
- DOI -
- Views 39
- Downloads 0
The effect of GLP-1 agonist (Liraglutide) on the neurological scores, Blood –brain barrier, brain water content and vestibulomotor function after severe traumatic brain injury in male rat: the role of IL-1β and IL-10
Introduction: Liraglutide is a long-acting analogue of Glucagon-like peptide-1 (GLP-1) that is primarily used in type 2 diabetes and obesity. It stimulates GLP-1 receptors and insulin secretion, and is dose-dependent and...
The neuroprotective effects of rivastigmine on brain edema, blood-brain barrier and neurological score after severe traumatic brain injury in male rat: a behavioral, biochemistry and histological study
Introduction: Traumatic brain injury (TBI) is the cause of death and disability among all age groups, along with social and economic effects. Rivastigmine is one of the drugs used in the treatment of Alzheimer's, dementi...
MRI-based quantification of grey matter reduction in brain areas along neural pathways in schizophrenia
Schizophrenia is a critical disorder with a difficult diagnosis and no promising treatment. Therefore, it is important to address the neurological variation and the brain abnormalities linked to schizophrenia. In this pa...
Beneficial effects of levetiracetam in streptozotocin-induced rat model of Alzheimer’s disease
Alzheimer’s disease (AD) is the most common neurodegenerative disorder among the elderly. In the light of increasing AD prevalence and lack of effective treatment, new strategies to prevent or reverse this condition are...
The effect of intracerebroventricular injection of ghrelin receptor antagonist on the extinction and reinstatement phases following morphine induce conditioning place preference in male rat: a behavioral and biochemical study
Introduction: This increases the release of dopamine in the nucleus accumbens, which determines the sensation of pleasure. The ghrelin receptor is located in many areas of the brain associated with pleasure, reward, and...