BACTERIA IN CANCER THERAPY: AN EMERGING ROBUST STRATEGY
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2013, Vol 4, Issue 5
Abstract
Cancer is one of the leading causes of death in the world. Solid tumors account for 90% of all cancers. Despite rapid developments in the conventional modalities of cancer treatment (chemotherapy and radiotherapy) there is still no definitive “cure” for cancer. The present observation aims to an eye on alternative cancer therapies. The search for alternative therapies dates back to early 1800’s when a patient was observed to recover spontaneously following an infection. This resulted in the birth of Coley’s toxin for the treatment of sarcomas and use of live Bacillus Calmette – Guerin (BCG) for bladder cancer. The same provoked for a series of researches in this field, but was heralded due to lack of specificity, lack of complete tumor lyses and ineffectiveness against small tumors. However with the advent of recombinant DNA technology and its developments, it has paved the way for a new era for a tumor- targeted bacterial vector system for gene therapy of solid tumors. In this review we will discuss the potential of genetically manipulated bacteria that will usher in the new era of bacterial therapy for solid tumors.
Authors and Affiliations
Preenu Sen, Gautham A, Murugan Manavalan, Ani Mansoor
Keywords
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- EP ID EP135810
- DOI 10.7897/2230-8407.04501
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