NON INVASIVE THERAPEUTIC DRUG MONITORING OF PROPRANOLOL HYDROCHLORIDE BY REVERSE IONTOPHORESIS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 4
Abstract
Therapeutic drug monitoring (TDM) is highly required for drugs possessing narrow therapeutic index as a slight variation in the therapeutic range could result in no or low clinical efficiency or causes significant side effects or high risk of toxicity. In recent days, reverse iontophoresis technique has been attempted for the non invasive drug monitoring. Typically, it applies a low electric current through a pair of skin electrodes to promote the transport of both charged and neutral molecules. Transdermal iontophoretic extraction of propranolol was carried out and the study involves effect of different solvents having their different pH values on the iontophoretic extraction, effect of different voltages on the iontophoretic extraction, effect of different permeation enhancers on the permeability of propranolol hydrochloride and the effect of stratum corneum removal on the permeability of propranolol. Iontophoretic diffusion was carried out in vitro using full thickness rat skin. The efficient quantity of propranolol was collected at cathode by electromigration. The correlation between the extracted fluxes of propranolol and its subdermal concentration was found to be adequate. The values of extraction fluxes didn’t attain a steady state throughout the experiment. The decrease in the solvent pH doesn’t affect the transdermal extraction of propranolol. The decrease in the voltage causes diminishes in the iontophoretic fluxes. The application of permeation enhancers especially propylene glycol causes significantly increase in the iontophoretic fluxes of propranolol. Thus it is concluded that propranolol hydrochloride can be quantitatively extracted by reverse iontophoresis in varying conditions of subdermal concentration.
Authors and Affiliations
Ankit Goel , Vipin Saini , Anroop Nair
Keywords
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