Benefits of alpha-ketoglutarate versus succinate on rat muscle dysfunction as a result of exposure to a uremic environment[sub][/sub]
Journal Title: Journal of Pre-Clinical and Clinical Research - Year 2007, Vol 1, Issue 1
Abstract
Muscle weakness is a prominent feature of end-state renal failure. While the cause of this strongly disabling muscle condition is at present unknown, there are suggestions that metabolic factors may play a role in this type of muscle fatigue. In vitro measurements of muscle function of the fast-twitch extensor digitorum longus (EDL) muscle of adult rats was performed. Isolated muscles were exposed to either a normal ionic environment, a uremic environment – with and without alpha-ketoglutarate (AKG), or with and without succinate, before being field stimulated until they were almost totally fatigued. The addition of AKG to the uremic environment was found to restore muscle performance so that the muscles no longer differed significantly from those incubated in a normal ionic environment. Similar effects to those noted for AKG were observed for succinate. It is concluded that AKG and succinate have a positive and restorative effect on muscle fatigue in uremic fast skeletal muscles in vitro. This beneficial form of treatment is proposed to act at the in vitro isolated muscle level by means of phosphate-binding, as the literature shows that an elevated plasma Pi concentration with renal failure disrupts normal muscle function.
Authors and Affiliations
Else M. Bartels, Stefan G. Pierzynowski, Adrian P. Harrison
Keywords
Related Articles
- EP ID EP58571
- DOI -
- Views 75
- Downloads 0
Effects of infrasound generated in urban areas on health of people and animals – an attempt to localize environmental infrasound sources using computer simulations
Introduction. Inaudible but ubiquitous environmental infrasound undoubtedly affects the frame of mind and health of humans. Objective. The object of the study is to prove that civil engineering objects can be sources o...
No effect of 7-nitroindazole on the anticonvulsant action of vigabatrin and oxcarbazepine in pentylenetetrazole-induced seizures in mice
The aim of this study was to determine the effect of 7-nitroindazole (7-NI – a preferential neuronal nitric oxide synthase inhibitor) on the protective action of oxcarbazepine (OXC) and vigabatrin (VGB) – two newer anti...
Influence of phototherapy on sensorimotor excitability of healthy muscle
The aim of this study is to assess the influence of laser irradiation and incoherent infrared radiation on sensorimotor excitability and muscle pain after a workout. The research was carried out on 40 healthy volunteers...
Epidemiology of non-invasive Aspergillosis of the maxillary sinuses – Clinical data from the Maxillofacial Surgery Clinic of the Medical University in Lublin, Poland, 2005–2014
Fungi are organisms which occur in the human environment. One of the potential pathogenic fungi is Aspergillus which belongs to mould, and is an etiological factor of non-invasive fungal paranasal sinusitis. Objective....
Characterization of acute adverse-effect profi le of carbamazepine and valproate in the grip-strength test in mice
The aim of this study was to assess the acute adverse (neurotoxic) effects of two conventional antiepileptic drugs (carbamazepine and valproate) in the grip-strength test by measuring skeletal muscular strength in mice....