Bioassay Guided Fractionation and α-Amylase Inhibitory Activity of Lupeol from the stem bark of Faidherbia albida Del. Mimosaceae
Journal Title: International Journal of Pharmaceutical Science Invention - Year 2017, Vol 6, Issue 6
Abstract
The present study was designed to isolate active compound(s) through activity guided isolation using α-amylase inhibitory activity of crude extract and fractions of Faidherbia albida . The crude and fractions were subjected to inhibitory effect on α-amylase. The ethylacetate fraction showed 91.63% inhibition of the enzyme, column chromatography of the ethylacetate fraction afforded the Compound EFAE 5 which inhibited the enzyme by 82.88% and showed significant α-amylase inhibition. Spectral analysis of the isolated compound confirmed it to be Lupeol by comparison of the spectral data with literature.
Authors and Affiliations
A. J. Kashimawo, J. A. Kolawole, A. A. Ahmadu
Keywords
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