Biomarkers of exposure and effect of organophosphorus compounds (literature review and results of own studies)
Journal Title: Український журнал сучасних проблем токсикології - Year 2018, Vol 84, Issue 4
Abstract
Objective: analysis and summary of the literature data and own studies on the possibility of using biomarkers of exposure and effect of organophosphorus compounds (OPCs), determination of immunological biomarkers of the effect under exposure to OPCs that cause delayed neurotoxicity (DN). Materials and Methods. Analytical methods were used in the work: collection of scientific information on the topic, analysis of data and scientific summary of the results. Re-assessment of the effect of OPCs causing DN was performed from the perspective of determination of the most informative immunological biomarkers of the effect of known neurotoxicants. Analysis of the study results of the effect of neurotoxic OPCs, triorthocresyl phosphate (TOCP), Afos on the immune system was performed using the most sensitive model — chicken breed Leghorn in isotoxic doses (500 mg/kg and 200 mg/kg, respectively) using common immunotoxicology methods. Results and Conclusions. The article analyses and concludes current literary data on the justified use of biomarkers of exposure and effect of OPCs that are widespread in the environmental objects and are one of the reasons of acute and chronic poisoning in the population. We’ve reviewed aspects of the necessity for implementation of scientifically justified approach to the development and assessment of biomarkers and creation of the unified diagnostic complex that includes biomarkers of exposure, specific and non-specific action, with wider diagnostic abilities compared with determination of isolated parameters that is the basis for diagnostics, efficient treatment and prediction of consequences of poisoning with OPCs. Based on the results of own studies, we proposed the use of some parameters as the immunological biomarkers of the effect of OPCs with DN: the level of finely dispersed circulating immune complexes in the blood serum and the level of anti-brain antibodies, the number and functional activity of blood neutrophils; the number of T-and B-lymphocytes and their functional activity; the number of NK-cells, T-helper cells, and T-suppressors.
Authors and Affiliations
O. V. Fedchenko, P. G. Zhminko
Keywords
Related Articles
- EP ID EP521624
- DOI 10.33273/2663-4570-2018-84-4-19-35
- Views 121
- Downloads 0
Use of the benchmark dose approach for evaluation of dose and time-dependent response to 7-hydroxycoumarin 90-day exposure in rat females
Benchmark dose (BMD) analysis of existing data sets from experimental studies on animal for which NOAEL/LOAEL information is available allows to satisfy the need for quantifiable, scientifically justifiable approach to r...
Study of the effect of four generic lambda-cyhalothrin pesticides on the reproductive function of male wistar han rats
Introduction. Objective is to identify hazard and asses reproductive toxicity risk of four generic lambda-cyhalothrin pesticides of different purity on male Wistar Han rats. Methods. Lambda-cyhalothrin (LC1 — 97 %, LC2 —...
Науковий діапазон вченого. (До 80-річчя доктора біологічних наук В. Д. Чміля)
До 80-річчя доктора біологічних наук В.Д. Чміля Іде людина, живе людина — і сонцем світиться вона. У неповторності єдина і у повторності одна. Саме такі слова спадають на думку під час спілкування з Віталієм Даниловичем...
Семейство ядерных рецепторов — активаторов пролиферации пероксисом (PPARs): биологическая роль в метаболической адаптации Часть ІІІ. PPARg в энергетическом гомеостазе и формировании метаболического синдрома, гепатостеатоза, сеpдечно-сосудистой патологии и фиброза (сообщение 1)
Цель. Проанализировать и обобщить современные представления о биологической роли в организме ядерного гормонального рецептора-активатора пролиферации пероксисом гамма (PPARγ), являющегося транскрипционным фактором, модел...
Гематотоксичность как проблема токсикологии химических веществ и некоторые подходы к ее решению
В комплексной оценке токсических свойств пестицидов при гигиеническом нормировании обязательной составляющей являются гематологические исследования, позволяющие оценить неблагоприятные эффекты на систему крови и разработ...