Calotropis gigantea (L.) Dryand – A review update
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2015, Vol 3, Issue 3
Abstract
Calotropis gigantea (L.) Dryand (Giant milk weed; family Asclepiadaceae) has been traditionally used in the treatment of bronchitis, asthma, leprosy, eczema and elephantiasis. This review emphasizes on ethnopharmacology, chemical constituents and pharmacology of C. gigantea. The available information on C. gigantea was collected through electronic search of major scientific databases. A survey of literature revealed that cardenolides, flavonoids, terpenoids, glycosides, steroids and nonprotein amino acid constitute major groups of chemical constituents in C. gigantea. The plant has been evaluated for varied pharmacological activities, and reported to exhibit analgesic, antimicrobial, antioxidant, anti-pyretic, anti-inflammatory, insecticidal, cytotoxic, hepatoprotective, pregnancy interceptive, procoagulant and wound healing activities. Further, thorough scrutiny of literature revealed a startling fact that clinical reports are not available on the plant. The pharmacological work carried out on the plant for validation of its traditional claims is not convincing as crude extracts used in experimental studies have not been characterized. It is concluded that C. gigantea is a medicinally promising plant, which needs to be exploited systematically. The plant could provide therapeutically active constituents, which may be developed as clinically potential drugs.
Authors and Affiliations
Deepak Kumar, Suresh Kumar
Keywords
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