Cognitive function in patients with hypertension and hypothyroidism with retrospective evaluation of disease control
Journal Title: Український неврологічний журнал - Year 2019, Vol 0, Issue 2
Abstract
Objective — to study the relationship between the clinical and anamnestic characteristics of patients with arterial hypertension (AH), hypothyroidism, AH comorbidity with hypothyroidism and cognitive function impairment. Methods and subjects. 67 patients (36 men and 31 women) were examined. The age was 47 (49.84 ± 2.83) years. Patients were distributed into 3 groups: I — 21 patients with AH and antihypertensive therapy; II — 18 patients with hypothyroidism who took 100 — 150 mg L‑thyroxin; III — 28 patients with AH with accompanying hypothyroidism and relevant therapy. Control group included 18 patients without AH and hypothyroidism in anamnesis. Records on annual visits to GP and endocrinologists were used for carrying out an analysis. Outpatient cards containing blood pressure and TSH findings during the course of the disease were worked out. To unify the approaches to data collection, a special form to fill in the obtained findings was elaborated. To evaluate the presence and degree of cognitive impairment, a brief scale of mental state assessment MMSE (Mini Mental State Examination) and Addenbrooke Scale (ACE) was applied. Results. While analyzing office blood pressure findings in Group 1, Group 3 and Control Group, a sufficient control at the time of examination was noted. A retrospective analysis of medical records revealed insufficient blood pressure control in the respective groups, the average level of SBP/DBP was 153.30 ± 0.64/97.50 ± 0.38 mm Hg. A retrospective analysis of the findings was performed and it was found out that the average TSH level was insufficiently adjusted in the patients under study (7.14 ± 2.37 and 8.03 ± 3.77 mIU/l in Group 2 and Group 3 respectively.) While conducting an individual assessment of MMSE test, the ratio of patients with cognitive impairment in Groups 1 — 3 was 3.6; 7.2 and 10.8 % respectively. Thus, the MMSE test findings in Group 3 are significantly lower in comparison with those in Group 1 and Group 2 — by 10.8 and 7.2 %, respectively. Conclusions. A retrospective analysis of medical records revealed an inadequate long‑term blood pressure and TSH control, which in turn caused the development of cognitive impairment in this group of patients. Future prospects for further research include the use of the obtained data for the purpose of cognitive impairment early detection.
Authors and Affiliations
M. I. Lesiv
Keywords
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- EP ID EP670591
- DOI 10.30978/UNJ2019-2-40
- Views 108
- Downloads 0
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