Combined Royal Jelly and Environmental Enrichment Effects Against Chronic Stress-Induced Memory Impairment
Journal Title: The 2nd Annual Meeting of International Center for Neuroscience Research - Year 2021, Vol 2, Issue 1
Abstract
Background & Aims: Exposure to chronic stress has been demonstrated to impair memory processing. The effective therapeutic ways such as enriched environment (EE) and royal jelly (RJ) have been indicated in previous studies. Given the neuroprotective effects of RJ and EE, the present study investigated the effects of EE, RJ, and combined effect on chronic stress-induced memory impairment. Methods: Rats were subjected to restraint stress (2 h/day for 10 days) under cold temperature (4°C) prior to treatment with RJ or/ and EE for 14 days. Following the interventions, novel object recognition memory (NORM) and inhibitive avoidance performance, hippocampal, and PFC BDNF expression were assessed. Results: Results showed that plasma corticosterone levels increased in the stressed rats. Also, the present findings revealed the dysfunction of short-term NORM among the rats exposed to chronic stress. Furthermore, stress induced deficits in passive avoidance performance, NORM, decreased BDNF levels in the hippocampus, and prefrontal cortex were improved following EE and RJ administration. Conclusion: In conclusion, EE and RJ via mediating BDNF expression in susceptible brain areas can protect these brain areas against chronic stress.
Authors and Affiliations
Amir Mohammad Ghorbanpour, Meysam Saboor, Reza Panahizadeh, Hakimeh Saadati*, Masoomeh Dadkhah*
Keywords
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