Comparative analysis of travoprost (0.004%) and bimatoprost (0.03%) on intraocular pressure in patients with open-angle glaucoma
Journal Title: Medpulse International Journal of Ophthalmology - Year 2018, Vol 6, Issue 1
Abstract
Purpose: To compare the efficacy and safety of bimatoprost (0.03%) and travoprost (0.004%) in newly diagnosed cases of open angle glaucoma. Material and Methods: Newly diagnosed patients of open angle glaucoma were recruited in this prospective study and were randomized to receive either bimatoprost or travoprost, once daily. The Intraocular pressure (IOP) was measured at baseline and then after one week, 1 month, 3 months, 6 months and 1 year. Adverse events, if any were also noted. Results: Mean IOP level recorded at baseline was 21.4 mmHg in the bimatoprost and 20.6 mmHg in the travoprost group. In the bimatoprost group the reduction of IOP after one week, 1 month, 3 months, 6 months and 1 year was 17.7, 15.2, 14.8, 14.8 and 14.6 respectively. In the travoprost group the reduction of IOP after one week, 1 month, 3 months, 6 months and 1 year was 17.5, 16, 15.4, 15.3 and 15 respectively. Most commonly reported adverse event in both groups was conjunctival hyperemia which was higher in the bimatoprost group (38.1%) than in the travoprost group (26.0%). Although both bimatoprost and travoprost effectively lowered IOP, bimatoprost provided larger mean IOP reductions than travoprost. Conjunctival hyperemia was most common adverse event but the patients tolerated medications well over the study period. Findings of our study could be very useful to treat patients of open angle glaucoma in the Indian population. Clinical significance: Bimatoprost (0.03%) and travoprost (0.004%) provided large reduction in mean IOP from baseline in cases of primary open angle glaucoma, normal tension glaucoma and ocular hypertension; however bimatoprost could be preferred for more effectiveness. Both were equally safe for ocular use.
Authors and Affiliations
Aruna Kumari, Roopam Gupta
Keywords
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- EP ID EP461558
- DOI 10.26611/1009612
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