Comparative evaluation of the role of centchroman and evening primrose oil in the regression of fibroadenoma of breast
Journal Title: Medpulse International Journal of Surgery - Year 2019, Vol 10, Issue 2
Abstract
Background: Fibroadenoma is common among women in reproductive age group. Still treatment for this condition is not standardised. Most of the drugs used are expensive and have side effects. Centchroman is a non-steroidal, selective anti-oestrogen and has the advantages of less frequent administration and is free from side effects of steroidal agents, whereas, the efficacy of commonly used evening primrose oil is still in debate.Aim: To assess the role of Centchroman versus evening primrose oil in the regression of fibroadenoma of breast.Material and Methods: Eighty patients were diagnosed with fibroadenoma and they were divided into two groups. One group was given Centchroman 30mg OD alternate days and the other group was given Evening primrose oil 500 mg BD daily for a period of 3 months and followed up for next 3 months. Patients were followed up with clinical examination and ultrasound breast.Results: 8 (20%) fibroadenomas in Centchroman arm disappeared completely as compared to four (10%) in Evening primrose oil arm over a period of 6 months. There was a decrease in the volume of fibroadenoma in eight (20%) patients in Evening primrose oil arm and 28 (70%) patients in Centchroman arm. Centchroman therapy allowed 20% fibroadenoma to regress completely with scanty menses or amenorrhea as the only side effect.Conclusion:Centchroman at a dosage of 30 mg daily for 3 months allowed complete regression of 20% of fibroadenoma, whereas only 10% of lesions regressed completely with Evening primrose oil.
Authors and Affiliations
RAnandh Balaji, Ranjan James Premkumar
Keywords
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- EP ID EP613884
- DOI 10.26611/1061021
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