Comparison of 24 Hour Urine Creatinine Clearance with Estimated GFR Using 2009 CKD-EPI Formulae
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2018, Vol 6, Issue 9
Abstract
The Glomerular filtration rate (GFR) is useful in the detection and estimateon of prognosis of chronic kidney disease (CKD) patients. Several methods are available to measure or estimate the GFR. The 24 hour urine collection for the estimation of GFR has been shown by studies to be more reliable than serum creatinine-based eGFR formulae. The eGFR by creatinine based formulae is known to be rapid and reliable means of approximation of creatinine clearance. The most commonly used equations to estimate GFR are serum creatinine based 2006 MDRD and 2009 CKD-EPI formulae. The objective of this study is to compare 24 hour urine creatinine clearance with estimated GFR using 2009 CKD-EPI and to identify at which stage of CKD the estimated GFR correlates closely with 24 hour urine creatinine clearance. It is a retrospective study. The laboratory requisition for 24 hour creatinine clearance in the period from January 2015 to December 2015 was collected retrospectively. There was a total of 120 laboratory request for 24 hour creatinine clearance in the specified period. Out of the total 120 patients, 46 were female patients with age range (18-75 years) and 74 were male patients with age range (18-75 years).The eGFR by CKD-EPI formulae had a statistically insignificant p-value (p > 0.05) in the III nd, IV thand Vthstages of CKD. This showed that 2009 CKD-EPI formulae had good approximation of 24 creatinine clearance in three stages of CKD. The 2009 CKD-EPI creatinine based GFR estimation provides a more accurate assessment of 24 hour creatinine clearance in in the IIInd, IVthand Vthstages of CKD. It is a good measure of kidney function than measuring serum creatinine alone but has certain limitations.
Authors and Affiliations
Dr. R. Mohan Doss
Keywords
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