Comparison of different doses of Injection Cisatracurium to establish optimal dose for reduction of propofol injection pain
Journal Title: Medpulse International Journal of Anesthesiology - Year 2019, Vol 9, Issue 1
Abstract
Background and Aims: The aim is to compare different doses of injection Cisatracurium given prior to injection propofol intravenous (IV) with venous occlusion by applying tourniquet for thirty seconds; and to establish the optimal dose of it. It is recommended for prevention of pain associated with propofol injection; and is to be compared with that of lignocaine injection for patients undergoing general anaesthesia. Methods: Patients undergoing operations with general anaesthesia are randomized to receiveeither injection 0.9% normal saline (control group) NS, Inj.Lignocaine (0.5 mg/kg) L, Inj. Cisatracurium (0.03 mg/kg) C1, Inj. Cisatracurium (0.1mg/kg) C2 and Inj. Cisatracurium (0.15 mg/kg) C3. All study drugs are administered into largest vein of hand with tourniquet applied for 30 seconds, followed by propofol injection (0.5 mg/kg). Pain is evaluated using four-point scale. Results: The propofol injection pain was definitely lower in pre-treatment with venous occlusion for 30 seconds in 0.1 mg/kgInj. Cisatracurium C2,0.15 mg/kg Inj. Cisatracurium C3 group and inInj. Lignocaine L group, than 0.03 mg/kg Inj.Cisatracurium C1 and control group with 0.9% normal saline NS given intravenously. There was no significant in-between difference with 0.1mg/kg Inj. Cisatracurium C2 group and 0.15mg/kg Inj. Cisatracurium C3 group. There was significant difference between injection 0.5mg/kg Inj. Lignocaine L, 0.1 mg/kg Inj. Cisatracurium C2 and 0.15mg/kg Inj. Cisatracurium C3 groups for pain perception with propofol injection given intravenous following tourniquet release after 30 seconds. Conclusion: Pre-treatment with venous occlusion for 30 seconds with0.1mg/kg Inj. Cisatracurium C2 decreases the propofol injection pain as effectively as 0.15mg/kg Inj. Cisatracurium C3; and that may be an optimal dose without significant complications.
Authors and Affiliations
Shobha Vatkar, Shilpa Gurav
Keywords
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- EP ID EP440298
- DOI 10.26611/1015918
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