COMPARISON OF DIFFERENT GRANULATION TECHNIQUES FOR LACTOSE MONOHYDRATE
Journal Title: International Journal of Pharmaceutical Sciences and Drug Research - Year 2011, Vol 3, Issue 3
Abstract
The objective of this study was directed to improve the physical and technical properties of poorly flowing and highly cohesive Lactose monohydrate to solve the most important problem that affects tablet manufacture. To overcome all the problems related to lactose granulation is required. Granulation is one of the most important unit operations in the production of pharmaceutical oral dosage forms. Granulation process will improve flow and compression characteristics, reduce segregation, improve content uniformity, and eliminate excessive amounts of fine particles. The results will be improved yields, reduced tablet defects, increased productivity. Pharmaceutical products are processed all over the world using the direct-compressing, wet-granulation, or dry granulation methods. Which method is chosen depends on the ingredients individual characteristics and ability to properly flow, compresses, eject, and disintegrate. Then the proper granulation process can be applied. The objective of present article was to focus on the best possible granulation technology that gives good results based on evaluation of different granule properties, namely the Carr’s index, Hausner’s index, Angle of repose, were evaluated for granule prepared by different binders and different techniques. Finally, the tabletting process showed low values of ejection forces, good tablet properties (weight uniformity, hardness, friability, and disintegration) indicating good compressibility of the prepared granules using Fluidized Bed Processor (HPMC 2.5% as binder) and Coprocessing of Lactose.
Authors and Affiliations
Pankaj Patel, Darshan Telange, Nitesh Sharma
Keywords
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- EP ID EP624949
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