Comparison of intramuscular atropine and glcopyrrolate in children undergoing various surgical procedures under general anaesthesia
Journal Title: Medpulse International Journal of Anesthesiology - Year 2018, Vol 7, Issue 2
Abstract
Background: Antiocholinergic premedication in paediatric patients undergoing surgeris under general anaesthesia plays in important role in blocking the potentially dangerous vagal reflexes and in also controlling the oropharyngeal secretions and respiratory secretions. Aim and objective: To compare the clinical effects of intramuscular atropine 0.02 mg/kg and intramuscular glcopyrrolate 0.01 mg/kg as premedicant drugs in children undergoinig various surgical procedures under general anaesthesia. Methodology: 50 children in the age group 5-19 yrs were allocated to 2 groups of 25 each. Glycopyrrolate was administered at the dose of 0.01 mg/kg IM and atropine 0.03 mg/kg IM, half an hour before surgery. The following clinical parameters were compared at different time intervals heart rate, temperature and dryness of mouth. In the post operative period incidence of nausea and vomiting was compared in both the groups. Results and discussion: Majority of the children who received intramuscular glycopyrrolate 0.01 mg/kg showed sable heart rate, superior antisialogogue action, minimal or no rise in body temperature compared to children receiving intramuscular atropine 0.02 mg/kg. The incidence of postoperative nausea and vomiting was less in the glycopyrrolate group, but this was not statistically significant compared with the incidence in the atropine group.
Authors and Affiliations
Raja shekar Reddy Motkar, Venkatesh Babu Thippeswamy, Surendra M Chinnappa
Keywords
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