Correlation between High-density Lipoprotein Cholesterol Level and CD4 Cell Count in HIV Patients on NNRTI-based ART Regimen at Tertiary Care Hospital in Mysuru
Journal Title: INTERNATIONAL JOURNAL OF SCIENTIFIC STUDY - Year 2017, Vol 5, Issue 3
Abstract
Introduction: India accounts for roughly half of Asia’s HIV prevalence. ART can prolong quality of life in HIV infected patients.The current follow up pattern in India is on the basis of CD4 counts which are done in higher ART centers once in 6 monthsThe lipid derangement is very well known to happen in HIV patients patients on ART. In this study we tried to evaluate changes in lipid profile with CD4 counts of patients on ART.Since lipid profile can be done even in peripheral set up and it is economical, it will help in the management of HIV patients in peripheral centres Material and Methods: 102 HIV patients visited ARTC at KR Hospital Mysore (starting from Dec 2013 to Dec 2014) age group between 20-50 yrs on NNRTI based ART for a minimum of 3 months are included in this study. For all the patients CD4 count leveland lipid profile is done. Results: Out of 102 patients included in the study, majority were males [73%] and mean age group was 37.12 yrs. when CD4 count considered, majority of females [86%] had CD4 count >200. This may indicate good drug compliance among females when considered to males.Correlation analysis shows that there is significant correlation between CD4 count and HDL while other parameters of lipid profile show no significant correlation. This concludes high HDL value in a patient on NNRT can indicates high CD4 count and a good immunity. Conclusion: This study confirms that, the HDLcholeterol has significant impact in predicting the level of CD4 cell counts in treating with NNRTI ART regimen and we found positive correlation between both the parameters.So HDL cholesterol Which is more economical test, even can be done in peripheral centres to assess the over all general condition of the patients on ART.
Authors and Affiliations
Dr Rangaswamy, K Soumya
Keywords
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