Correlation between iron status and thyroid function in betathalassemia major of Iraqi patients
Journal Title: IOSR Journal of Biotechnology and Biochemistry (IOSR-JBB - Year 2018, Vol 4, Issue 3
Abstract
Iron overload is an important issue in the state of thalassemic patients due to the harmful effect of high concentration of iron deposited in different tissues in the human body including endocrine glands. In the present work, an attempt is carried out to estimate the effect of different levels of iron body status on the function of thyroid glandsin thalassemic major patients in relation to TPO antibodies. One hundred thirty βthalassemia major patients divided intothree groups; two groups (low iron overload and high iron overload) and sixty-five healthy persons as control groups.Blood samples were taken in the fasting to check laboratory tests such as ferritin, T3, T4, TSH and TPO estimated by ELISA technique and iron status estimated by spectrophotometer technique. 119(61%)of patients had Euthyroid, 13(6.7%) subclinical hypothyroidism, 63 (32.3%) had hypothyroidism with a significant difference when compared to healthy control group while there was no significant statistical difference in TPO level between different studied groups (p-value ≤ 0.001). In the current study, there was no significant correlation between T3, T4 and TSH with different serum ferritin levels. Thyroid dysfunction (hypothyroidism and subclinical hypothyroidism) is common among Iraqi thalassemia major patients with iron overload, and it’s unrelated to different serum ferritin levels, and the increasing presence of TPO antibodies among these patients with moderate correlation may be due to immunogenicity changes due to the direct effect of iron on thyroid tissue.
Authors and Affiliations
Shahad FObeid, Sanad B. AL- A'Araji, Bassam FMatti
Keywords
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- EP ID EP415111
- DOI 10.9790/264X-0403017477.
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