Correlation of serum calcium, phosphorus and alkaline phosphatase levels with eGFR in newly diagnosed chronic kidney disease patients
Journal Title: Medpulse International Journal of Biochemistry - Year 2019, Vol 9, Issue 2
Abstract
Background: Chronic kidney disease or chronic renal failure is a health problem affecting mainly the elderly population. Chronic kidney disease (CKD) leads to many serious and life threatening complications like dyslipidemia, cardiovascular disease anemia and bone related problems. Bone related problems like renal osteodystrophy is one among the long term dreaded complications of CKD. Recently, CKD-MBD (Chronic kidney disease Bone mineral disorder) is the term used to describe all the bone associated defects arising due to long term CKD. CKD-MBD is one of the major risk factors for cardiovascular mortality2. With this background we decided to estimate serum calcium, phosphorus and alkaline phosphatase (ALP) levels in various stages of newly diagnosed chronic kidney disease patients and to correlate the values with eGFR (severity) in newly diagnosed chronic kidney disease patients. Only newly diagnosed CKD patients were taken as cases to avoid the influence of treatment (like calcium supplementation) on the levels of blood calcium, phosphorus and alkaline phosphatase. Material and Method: It was a case control study with 79 controls (eGFR>60) and 93 newly diagnosed CKD cases (eGFR < 60 ml/min/1.73 m2). CKD patients again divided into 3 subgroups - 43 stage 5 (eGFR < 15ml/min/1.73 m2), 25 stage 4 (eGFR 15 -29 ml/min/1.73 m2) and 25 stage 3 (eGFR 30-60ml/min/1.73 m2) CKD patients Result: The mean values of calcium (8.65 + 1.1mg/dl), phosphorus (4.72 + 0.96mg/dl) and ALP (154.78 + 50.15U/L) in the study group are significantly different than the control group in which the mean levels are 9.85 + 1.4 mg/dl, 3.2 + 0.53mg/dl and 102.1 + 51.44U/L respectively. eGFR has a strong negative correlation with phosphorus and ALP and a strong positive correlation with calcium in both stage 4 and 5 CKD Conclusion: Our study shows that as the severity of CKD increases as evidenced by decrease in eGFR, more is the change in bone mineral levels and the severity of bone disease of CKD also increases.
Authors and Affiliations
Manju M, Suryapriya Rajendran, Sasmita Mishra, S Vithiavathi
Keywords
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- EP ID EP521702
- DOI 10.26611/1002923
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