Correlation of serum calcium, phosphorus and alkaline phosphatase levels with eGFR in newly diagnosed chronic kidney disease patients
Journal Title: Medpulse International Journal of Biochemistry - Year 2019, Vol 9, Issue 2
Abstract
Background: Chronic kidney disease or chronic renal failure is a health problem affecting mainly the elderly population. Chronic kidney disease (CKD) leads to many serious and life threatening complications like dyslipidemia, cardiovascular disease anemia and bone related problems. Bone related problems like renal osteodystrophy is one among the long term dreaded complications of CKD. Recently, CKD-MBD (Chronic kidney disease Bone mineral disorder) is the term used to describe all the bone associated defects arising due to long term CKD. CKD-MBD is one of the major risk factors for cardiovascular mortality2. With this background we decided to estimate serum calcium, phosphorus and alkaline phosphatase (ALP) levels in various stages of newly diagnosed chronic kidney disease patients and to correlate the values with eGFR (severity) in newly diagnosed chronic kidney disease patients. Only newly diagnosed CKD patients were taken as cases to avoid the influence of treatment (like calcium supplementation) on the levels of blood calcium, phosphorus and alkaline phosphatase. Material and Method: It was a case control study with 79 controls (eGFR>60) and 93 newly diagnosed CKD cases (eGFR < 60 ml/min/1.73 m2). CKD patients again divided into 3 subgroups - 43 stage 5 (eGFR < 15ml/min/1.73 m2), 25 stage 4 (eGFR 15 -29 ml/min/1.73 m2) and 25 stage 3 (eGFR 30-60ml/min/1.73 m2) CKD patients Result: The mean values of calcium (8.65 + 1.1mg/dl), phosphorus (4.72 + 0.96mg/dl) and ALP (154.78 + 50.15U/L) in the study group are significantly different than the control group in which the mean levels are 9.85 + 1.4 mg/dl, 3.2 + 0.53mg/dl and 102.1 + 51.44U/L respectively. eGFR has a strong negative correlation with phosphorus and ALP and a strong positive correlation with calcium in both stage 4 and 5 CKD Conclusion: Our study shows that as the severity of CKD increases as evidenced by decrease in eGFR, more is the change in bone mineral levels and the severity of bone disease of CKD also increases.
Authors and Affiliations
Manju M, Suryapriya Rajendran, Sasmita Mishra, S Vithiavathi
Keywords
Related Articles
- EP ID EP521702
- DOI 10.26611/1002923
- Views 134
- Downloads 0
A study of higher circulatory levels of uric acid in cardio vascular disease (CVD) patients
Uric acid is an end product of purine catabolism. It is observed that increased uric acid formation is associated with various inflammatory conditions. Anthropometric parameters as well lipid profile did not show any cor...
Serum glycoproteins in patients with severe depression compared with normal subjects
Background: Depressive illness is considered to be a psychoneuro-immunological disorder due to peripheral immune activation through the release of proinflammatory cytokines. Cytokines enhance the hepatic synthesis of gly...
Comparative assessment of oxidative stress and enzymatic antioxidants in primigravidae pregnant and non-pregnant women
Background: The generation of reactive oxygen species and the activation of antioxidant defence mechanisms are important components of female reproductive physiology. It's impairment alters cellular signalling and can da...
Study of serum Malondialdehyde, nitric oxide and vitamin E in rheumatoid arthritis patients before and after the supplementation of vitamin E
Background: Rheumatoid arthritis (RA) is a chronic systemic inflammatory disorder that may affect many tissues and organs – skin, blood vessels, heart, lungs and muscles but principally attacks the joints, producing a no...
Biochemical markers of oxidative stress pathways in major depression
Context: Depression is the major disorder in present scenario which needs essential attention to prevent significant negative impact on quality of life, mortality/ morbidity and cognitive function. Major depression is ch...