Curative effect of Ranibizumab combined with laser photocoagulation for proliferative diabetic retinopathy
Journal Title: Guoji Yanke Zazhi - Year 2018, Vol 18, Issue 4
Abstract
AIM:To investigate the clinical efficacy of Ranibizumab combined with laser photocoagulation in the treatment of proliferative diabetic retinopathy(PDR). <p>METHODS: Totally 80 patients(101 eyes)with PDR admitted to our hospital from October 2014 and October 2016 were selected and divided into the observation group and the control group, with 50 eyes and 51 eyes respectively. The patients in the control group(50 eyes)were treated with panretinal photocoagulation(PRP), and the patients in observation group(51 eyes)were treated with ranibizumab on the basis of PRP treatment. Best corrected visual acuity(BCVA)was compared before and after surgery 1, 3, and 6mo. Optical coherence tomography(OCT)was used to examine the central macular thickness(CMT)and the area of neovascularization at each timepoints. Then the laser spot number, laser energy and energy density were compared between the two groups and the adverse reactions were recorded. <p>RESULTS: Postoperative BCVA of the two groups significantly increased, and the BCVA of observation group were significantly higher than that of the control group after surgery 1, 3, 6mo, the difference was statistically significant(<i>P</i><0.05). After treatment, the CMT and neovascularization area of the two groups significantly decreased, and those of the observation group were significantly lower than those of the control group after surgery 1, 3, 6mo, the difference was statistically significant(<i>P</i><0.05). The laser spot number, laser energy and energy density of the observation group were significantly lower than those of the control group, the difference was statistically significant(<i>P</i><0.05). There were 2 cases(2 eyes)in the observation group and 1 cases(1 eye)in the control group, whose intraocular pressure exceeded 28mmHg, while relieved rapidly after the treatment, and no obvious complications occurred in two groups. <p>CONCLUSION: Ranibizumab combined with laser in the treatment of PDR is an effective and safe way to improve BCVA, reduce CMT, and eliminate new blood vessels with less required laser energy.
Authors and Affiliations
Fan-Yi Meng
Keywords
Related Articles
- EP ID EP656095
- DOI 10.3980/j.issn.1672-5123.2018.4.10
- Views 121
- Downloads 0
Related factors of vision recovery after complex traumatic and non-traumatic retinal detachment
AIM: To investigate the visual recovery factors in patients with complex traumatic and non-traumatic retinal detachment. <p>METHODS: According to the history of ocular trauma before admission, 135 patients with complex r...
Effect of blue light and white light on proliferation of ARPE-19 cells detected by CCK-8
AIM: To investigate the effects of blue light and white light on the proliferation of human retinal pigment epithelial cell line(ARPE-19)at different times, and lay a foundation for further detecting the changes of relat...
Research on correlation between diabetic retinopathy and dry eye
AIM:To research the correlation between dry eye and diabetic retinopathy(DR)in type 2 diabetes mellitus patients. <p>METHODS:A total of 150 patients with type 2 diabetes mellitus collected from August 2015 to February 20...
Effects of amniotic membrane transplantation combined with limbal stem cell autograft transplantation on ocular burns
AIM: To investigate the effects of amniotic membrane transplantation combined with limbal stem cell autograft transplantation on ocular surface repair time, repair rate and complications in patients with ocular burns. <p...
Changes of retinal nerve fiber layer thickness in patients with different types of angle-closure glaucoma
AIM: To investigate the changes and significance of retinal nerve fiber layer(RNFL)thickness in patients with acute and chronic angle-closure glaucoma. <p>METHODS: Totally 37 patients(40 eyes)with acute angle-closure gla...