CYTOGENETIC EFFECTS IN BONE MARROW CELLS AT THE FIRST GENERATIONS OFFSPRINGS OF THE RATS EXPOSED INCORPORATED 131I
Journal Title: Наукові праці. Серія "Техногенна безпека" - Year 2016, Vol 280, Issue 268
Abstract
Among the problems that emerged after the Сhernobyl NPP accident, the most important include the issue of transfer effect genomic instability through gametes irradiated parents to first generation of their descendants. The ability of the incorporated 131I influence to transgenerated effects studied in the experiment, which excluded the impact of non-radiation factors. Determined frequency and spectrum of chromosomal aberrations in bone marrow cells of rat offspring exposed incorporated 131I. Cytogenetic analysis in the offspring of both exposed parents and of irradiated females and intact males identified genetic disorders in bone marrow cells. The spectrum of chromosomal aberrations include almost all kinds of chromosomal damage. The frequency of chromosome aberrations type was significantly increased due to specific markers of radiation exposure, paired fragments, dicentrics and acentric rings. Results of the study confirmed the data of other authors the high sensitivity of the organism in the prenatal period to the mutagenic effects of radiation to induction of transgenerate of chromosomal instability
Authors and Affiliations
L. Neumerzhytska, N. Atamanyuk, O. Ganzha, I. Drozd, A. Lypska
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