Design and development of buccal tablets of Metoprolol tartarate by core in cup technology
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2018, Vol 6, Issue 3
Abstract
A precise, simple, cost effective, accurate Ultra violet spectrophotometric method has been developed for the determination of Edoxaban Tosylate Monohydrate (EDTM) in the Pharmaceutical dosage form. EDTM shows highest λmax at 291.2 nm. The EDTM follows linearity in the concentration range of 2-10 μg /mL with superior correlation coefficient value of 0.999. The precision of the method was studied as an intra-day and inter-day studies. The % RSD value is < 2 which indicates that the method is precise. The % recovery was found to be in the range lies between 99.75 - 99.85 %. Percentage assay of EDTM (Lxiana) obtained was 98.5 ± 1.85 %. The Proposed spectrophotometric method was validated as per the ICH Q2 (R1) guidelines. The proposed UV method is accurate, precise and reproducible. Hence this rapid method can be viable for the quality control analysis of EDTM in pharmaceutical dosage form.
Authors and Affiliations
N. NarasimhaRao, Alapati Dihitha chowdary, Yadala Divya, Kakani Sai Sneha Latha, Talakola Sri Lakshmi, Patibandla Sirisha
Keywords
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