Design and Development of Fast Dissolving Bi Layer Films for Hypertensive Emergencies
Journal Title: International Journal of Pharmaceutical and Medicinal Reserach - Year 2015, Vol 3, Issue 6
Abstract
The main aim of research work was to design novel bilayer fast dissolving films as a drug delivery system for treatment of severe hypertension and acute cases like angina pectoris. In present work two incompatible drugs Amlodipine and Benazapril was combined in single dosage form using impermeable membrane. The thin films of both drugs were prepared by using different concentration of polymers, plasticizers and super disintegrants. The films were casted in to bilayer films using impermeable membrane. These prepared Bilayer films were characterized on basis of thickness, folding endurance, tensile strength and dissolution time. On basis of study it was found that the optimized film dissolves within 60 sec. The animal Irritation study and Pharmacokinetic study is performed to ensure safety and Bioavailability of films in oral cavity. The proposed novel films will deliver the two incompatible drugs and releases the drug quickly thus can be preferred in hypertension emergencies.
Authors and Affiliations
Manjunath B Mendon, Devendra S. Rathore
Keywords
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