Design and Evaluation of Mouth Dissolving Tablet of Zopiclone using Different Superdisintegrants
Journal Title: Journal of Pharmaceutical Sciences and Research - Year 2010, Vol 2, Issue 8
Abstract
In the present work, Mouth dissolving tablet of Zopicolon were designed with a view to Enhance patient compliance. A combination of super-disintegrants i.e.Ac-di-sol (Croscarmellose sodium), Polyplasdone XL-10, Microcrystalline Cellulose pH 102 was Used along with directly compressible dextrose to enhance mouth feel. The prepared Batches of tablet were evaluated for hardness, friability, drug content uniformity, wetting time, water absorption ratio and in vitro dispersion time. Based on in vitro dispersion time, two formulation were tested for in vitro drug release pattern (in pH7.4 phosphatebuffer), short – term stability at 250 C 20 C/60% RH, 300 C 20 C/65% RH, 400 C 20 C/75% RH for 3 month and drug –excipient interaction (IR Spectroscopy) among the two formulation, the formulation prepared by direct Compression method using Ac-di-sol (croscarmellose sodium) 50mg, Polyplasdone XL- 10 -25mg, Microcrystalline Cellulose pH 102- 25mg was found tobe better formulation T80%= 5 min. based on in- vitro drug release characteristics. Short term stability studies on the formulation indicated that there is no significant change in drug content and in vitro dispersion time
Authors and Affiliations
D. G. Umalkar , B. Stephen Rathinaraj , G. S. Bangale , G. V. Shinde , D. Kumaraswamy , Ch. Rajveer , KS. Rajesh
Keywords
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- EP ID EP102596
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