Design and Evaluation of Mouth Dissolving Tablet of Zopiclone using Different Superdisintegrants
Journal Title: Journal of Pharmaceutical Sciences and Research - Year 2010, Vol 2, Issue 8
Abstract
In the present work, Mouth dissolving tablet of Zopicolon were designed with a view to Enhance patient compliance. A combination of super-disintegrants i.e.Ac-di-sol (Croscarmellose sodium), Polyplasdone XL-10, Microcrystalline Cellulose pH 102 was Used along with directly compressible dextrose to enhance mouth feel. The prepared Batches of tablet were evaluated for hardness, friability, drug content uniformity, wetting time, water absorption ratio and in vitro dispersion time. Based on in vitro dispersion time, two formulation were tested for in vitro drug release pattern (in pH7.4 phosphatebuffer), short – term stability at 250 C 20 C/60% RH, 300 C 20 C/65% RH, 400 C 20 C/75% RH for 3 month and drug –excipient interaction (IR Spectroscopy) among the two formulation, the formulation prepared by direct Compression method using Ac-di-sol (croscarmellose sodium) 50mg, Polyplasdone XL- 10 -25mg, Microcrystalline Cellulose pH 102- 25mg was found tobe better formulation T80%= 5 min. based on in- vitro drug release characteristics. Short term stability studies on the formulation indicated that there is no significant change in drug content and in vitro dispersion time
Authors and Affiliations
D. G. Umalkar , B. Stephen Rathinaraj , G. S. Bangale , G. V. Shinde , D. Kumaraswamy , Ch. Rajveer , KS. Rajesh
Keywords
Related Articles
- EP ID EP102596
- DOI -
- Views 134
- Downloads 0
Elevated concentrations of plasma homocysteine in coronary artery disease patients with normal folate level.
Hyperhomocysteinemia is becoming a growing concern as a risk factor in patients suffering from coronary artery disease. The purpose of our study was to evaluate the existence of hyperhomocysteinemia with folate levels a...
Spectrophotometric determination of Ceftiofur in pharmaceutical formulations by FGFCF, SFNO and MB
Three simple spectrophotometric methods are proposed for the determination of Ceftiofur (CEFT) in bulk drug and in pharmaceutical preparations. The method is based on oxidation product with Fast green FCF (FGFCF)/KMnO4-,...
Protective role of tetrahydrocurcumin and chlorogenic acid on glycoprotein<br /> changes in streptozotocin-nicotinamide-induced diabetic rats
The present study was to evaluate the individual and synergistic effect of two-plant derived phenolic compounds, namely tetrahydrocurcumin(THC) and chlorogenic acid (CGA) on glycoprotein levels in plasma, liver and kidne...
Physio- Phytochemical screening and Diuretic activity of leaves of Pavetta indica Linn
Pavetta indica Linn is used in the traditional medicine for many diseases.In the present study, the diuretic activity of Petroleum ether and Methanol extract of leaves of Pavetta indica was studied and the activity was...
Formulation and Evalution of pH–Induced Povidone Iodine in Situ Gel for Oralthrush
Candida species have become a major opportunistic pathogen causing recurrent oral thrush and oropharyngeal candidiasis topical delivery of antimicrobial agents is the most widely accepted approach aimed at prolonging act...