DESIGN, CHARECTERISATION AND INVITRO EVALUATION OF CLARITHROMYCIN LOADED EXTENDED RELEASE MUCOADHESIVE GRANULES BY SPRAY DRY METHOD AGAINST HELICOBACTOR PYLORI IN STOMACH
Journal Title: Mintage journal of pharmaceutical and medical sciences - Year 2017, Vol 6, Issue 4
Abstract
Objective: The purpose of the present research was to develop and characterize mucoadhesive microspheres of clarithromycin for the potential use of treating microbial infections, gastric and duodenal infections associated with Helicobacter pylori. Method: Clarithromycin mucoadhesive microspheres were prepared using Hydroxy propyl methyl cellulose as a matrix and carbopol 934P as a mucoadhesive polymer by an emulsion solvent evaporation technique. Drug entrapment efficiency (DEE), percentage mucoadhesion (PM), in vitro drug release and particle size (PS). Optimized formulation was obtained using desirability approach of numerical optimization. Results: The experimental values of DEE, PM, % release and PS after 8 h for the optimized formulation were found to be 50.256 ± 1.38%, 66.23%±0.06, 73.564 ± 1.32%, and 139.881 ± 2.56 µm, respectively. Conclusion: The drug release was also found to be slow and extended more than 8 h and release rates were fitted to the Power law equation and Higuchi model to compute the diffusional parameters. The prolonged stomach residence time of clarithromycin mucoadhesive microspheres might make a contribution to H. pylori complete eradication in combination with other antimicrobial agents.
Authors and Affiliations
Kumar P. Prem, Renuka . , Manohar Babu S.
Keywords
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