Abstract

Transdermal drug delivery system (TDDS) was planned to release the drug in appropriate manner and to improve patient compliance. Present study describes the alternative route for systematic delivery of drug into the body system which enhances the rate of absorption and increases the bioavailability of the drug into systemic circulation by reducing the gastic irritation. The purpose of the present investigation was to design and formulate TDDS of Paracetamol with various polymers such as hydroxyl methyl cellulose (HPMC), Xanthan gum etc along with to check the effect of penetration enhancers like dimethyl sulphoxide (DMSO) Oleic acid, Linseed oil on release of drug from patch system. Formulations were developed by solvent casting technique. to evaluate their characterastics such as Physical appearance, thickness, weight variations, drug content uniformity, folding endurance, tensile strength moisture content, moisture loss, flatness, surface pH, etc. In vitro drug release studies and stability study were also carried out. In vitro drug release study was also carried out by using PBS pH 7.4 and the samples were analyzed UV-spectrophotometrically at 249 nm. Formulations showed good uniformity of drug content; there was no any kind of effect on moisture loss test. Formulation F10 shows the release of drug 98.29% at the end of 7 h and was considered as a optimized formulation. A result of short‐term stability study indicated the formulations were remained stable both physically and chemically. Hence, aforesaid study accomplishes goal such as decrease frequency of administration, less dosing, improved patient compliance and reduced systemic toxicity.

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