Detection of Some Biomarkers in Iraqi Patients with Thyroid Carcinoma
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2017, Vol 12, Issue 4
Abstract
Background:Thyroid cancer, the most common endocrine malignancy, has increased dramatically in the lastyears.Cathepsin D and Galectin-3 have been implicated in the regulation of cellular growth, differentiation and malignant transformation in various organs including thyroid gland. It has been extensively studied as an immunohistochemical (IHC) of these markers in thyroid malignancy. Aim: To assess the diagnostic role of galectin-3 (Gal-3) and cathepsin D (CD) in thyroid neoplasm. Materials and Methods: In this study we evaluated Cathepsin D and Galectin-3expression in 43 of thyroid tissue cases, (23) thyroid malignant,(12) benign and (8) control cases. The final common diagnosis arrived at after histopathological evaluation of H&E stained sections by pathologist was considered the final H and E standard diagnosis. The malignant neoplasms included Papillary Thyroid Carcinoma (PTC), Follicular Thyroid Carcinoma (FTC), Medullary Thyroid Carcinoma (MTC), Anaplastic Thyroid Carcinoma (ATC) andHürthle cell cancer (HCC). The benign neoplasms included Follicular Adenoma (FA). IHC staining for CD and Gal-3 was performed for all cohort. Statistical Analysis: Statistical analysis was done by using Pearson and Spearman correlations to calculate pvalue to statistical significance. Results: CD and Gal-3 expression were significantly higher in malignant thyroid neoplasms as compared to benign neoplasms (p<0.01). As well highly significant correlation of expression between galectin-3 and cathepsin D (p<0.01). Conclusion: Diffuse and strong IHC staining for galectin-3 and cathepsin D in malignant, very weak stain score 1 inbenign tumour and no stain in control. These markers can be used in the diagnosis of thyroid neoplasms with equivocal morphologic features.
Authors and Affiliations
ReyadhSalim Mohammed1, Ban JasimMohamad, RanaZuhair Naji3
Keywords
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