Development and Evaluation Sustained release matrices of Lamivudine by using Synthetic Polymer
Journal Title: International Journal of Pharma Research and Health Sciences - Year 2014, Vol 2, Issue 3
Abstract
The present work is aimed at preparing and evaluating sustained release matrix tablets of Lamivudine using Synthetic polymer i.e. Glyceryl behenate (Compritol 888) with different polymers concentration by direct compression and Hot melt granulation techniques. Lamivudine is a potent hydrophilic anti viral agent indicated for treatment of AIDS (Acquired Immunodeficiency Syndrome). It was found that the cumulative percent drug release decreased with increasing concentration of Polymer. Matrix tablets were prepared by direct compression method and hot melt granulation technique taking Glyceryl behenate (Compritol 888) as different concentration in increasing order and F001 to F008 total eight formulation were prepared. The powders are evaluated for flow properties and tablets were evaluated for hardness, friability, dissolution rate, kinetics studies etc. No chemical interaction between Drug and the polymer were seen as confirmed by FT-IR studies. Among all the formulation made by direct compression and hot melt granulation it was found that the formulation containing Glyceryl behenate (Compritol 888) in higher concentration using Hot melt granulation showing best sustained release or retard the release of drug up to 24 hours
Dualwavelength & Q-Absorption Ratio Spectrophotometry Methods Development and Validation for Simultaneous Estimation of Metoprolol Succinate and Chlorthalidone in Bulk and Dosage Form
To develop and validate a simple & accurate Spectrophotometry methods for simultaneous estimation of Metoprolol Succinate and Chlorthalidone in their combined pharmaceutical dosage form. Two simple, accurate, precise U.V...
Screening of Analgesic Activity of Methanol Extract of Hypnea flagelliformis Greville ex J.Ag.(Red seaweed) in Koothankuzhi Coast Tamilnadu India
In the present study, an attempt was taken to determine the analgesic activity of methanolic extract of Hypnea flagelliformis Greville ex J.Ag. in Koothankuzhi coast, Tamil Nadu, India. Methods: The dried powdered Hypnea...
Antidiabetic Activity of Aerva lanata Linn Juss by Using Alloxan Induced Diabetic Rats
Objective: To prescreen the in vivo anti diabetic activity of the aerial parts of the plant Aerva lanata Family Amaranthaceae by using alloxan inducing diabetic rats. Method: In the present study to investigate the effec...
Management of Acute Renal Failure
Acute renal failure is the generic term for an abrupt and sustained decrease in renal function resulting in retention of nitrogenous (urea and creatinine) and non-nitrogenous waste products. Depending on the severity and...
Invitro Evaluation of Antioxidant and Antimicrobial Potential of leaves of Atalantia racemosa Wight ex Hook
Objective: Atalantia racemosa belongs to the family Rutaceae, comprises of 11 species which are closely-related. The present study was mainly done to evaluate the antioxidant and antimicrobial potential of leaves of Atal...