Development and validation of UV Spectrophotometric method for the determination of Bamifylline hydrochloride in pharmaceutical dosage form
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2017, Vol 5, Issue 3
Abstract
A simple, precise, cost effective, accurate UV- spectrophotometric method has been developed for the estimation of bamifylline hydrochloride in the Pharmaceutical dosage form. Bamifylline hydrochloride shows highest λmax at 263 nm. The bamifylline hydrochloride follows linearity in the concentration range of 2-10 μg /mL with good correlation coefficient value of 0.9997. The precision of the method was studied as an intra-day and inter-day studies. The % RSD value is less than two indicates that the method is precise. The % recovery was found to be in the range of 99.52 - 99.99%. Percentage assay of bamifylline hydrochloride tablets (Bamifix) got 99.83%. The Proposed spectrophotometric method was validated as per the ICH Q2 (R1) guidelines. The proposed UV method is precise, reproducible and accurate. Hence this rapid method can be feasible employed for the regular quality control analysis of bamifylline hydrochloride in pharmaceutical dosage form.
Authors and Affiliations
Panchumarthy Ravisankar, MD. Shaheem Sulthana, N. Sreenivasulu, D. Neelima Lakshmi, G. Lakshmi Priyanka, B. Pavan Kumar Reddy
Keywords
Related Articles
- EP ID EP33481
- DOI -
- Views 284
- Downloads 0
FORMULATION AND EVALUATION OF FLOATING DRUG DELIVERY SYSTEM OF CLARITHROMYCIN TABLETS
The present study focused on the development of gastroretentive technology which will deliver the antibiotic at predetermined rate to achieve the local concentration enough to act as antibacterial against H.Pylori. This...
FORMULATION AND E VALUATION OF FAMOTIDINE FAST DISSOLVING TABLETS BY DIRECT COMPRESSION METHOD
Fast dissolving tablets were highly accepted drug delivery system. Fast dissolving tablets were dissolved/ disintegrated in the mouth within a matter of few seconds without need of water. The aim of the present study wa...
HEPATOPROTECTIVE EFFECT OF HYDROALCOHOLIC EXTRACT OF Ocimum gratissimum LEAVES ON RIFAMPICIN-ISONIAZID INDUCED RATS
Ocimum gratissimum leaves used for treatment of jaundice in Ayurvedic medicine. Adult male wistar rats were rendered hepatotoxicity by Rifampicin-Isoniazid(50mg/kg each) by intraperitonially for 14days while leaf extra...
Classifications, properties and wide applications of nanomaterials
Nanotechnology has been developed for many years which it was not a new topic in science and was not a new technology. It is a part of science which has been developed a tremendous application for the remediation of en...
Analytical method development and validation for the simultaneous estimation of Levamisole and Mebendazole in bulk & tablet formulation by RP-HPLC method
A fast, robust and accurate RP-HPLC method was developed and validated for simultaneous determination of Levamisole and Mebendazole in tablets. The mobile phase was mixture of aqueous phosphate buffer with pH 5.2: Meth...