Development and validation of UV Spectrophotometric method for the determination of Bamifylline hydrochloride in pharmaceutical dosage form
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2017, Vol 5, Issue 3
Abstract
A simple, precise, cost effective, accurate UV- spectrophotometric method has been developed for the estimation of bamifylline hydrochloride in the Pharmaceutical dosage form. Bamifylline hydrochloride shows highest λmax at 263 nm. The bamifylline hydrochloride follows linearity in the concentration range of 2-10 μg /mL with good correlation coefficient value of 0.9997. The precision of the method was studied as an intra-day and inter-day studies. The % RSD value is less than two indicates that the method is precise. The % recovery was found to be in the range of 99.52 - 99.99%. Percentage assay of bamifylline hydrochloride tablets (Bamifix) got 99.83%. The Proposed spectrophotometric method was validated as per the ICH Q2 (R1) guidelines. The proposed UV method is precise, reproducible and accurate. Hence this rapid method can be feasible employed for the regular quality control analysis of bamifylline hydrochloride in pharmaceutical dosage form.
Authors and Affiliations
Panchumarthy Ravisankar, MD. Shaheem Sulthana, N. Sreenivasulu, D. Neelima Lakshmi, G. Lakshmi Priyanka, B. Pavan Kumar Reddy
Keywords
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