Development and validation of UV Spectrophotometric method for the determination of Bamifylline hydrochloride in pharmaceutical dosage form
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2017, Vol 5, Issue 3
Abstract
A simple, precise, cost effective, accurate UV- spectrophotometric method has been developed for the estimation of bamifylline hydrochloride in the Pharmaceutical dosage form. Bamifylline hydrochloride shows highest λmax at 263 nm. The bamifylline hydrochloride follows linearity in the concentration range of 2-10 μg /mL with good correlation coefficient value of 0.9997. The precision of the method was studied as an intra-day and inter-day studies. The % RSD value is less than two indicates that the method is precise. The % recovery was found to be in the range of 99.52 - 99.99%. Percentage assay of bamifylline hydrochloride tablets (Bamifix) got 99.83%. The Proposed spectrophotometric method was validated as per the ICH Q2 (R1) guidelines. The proposed UV method is precise, reproducible and accurate. Hence this rapid method can be feasible employed for the regular quality control analysis of bamifylline hydrochloride in pharmaceutical dosage form.
Authors and Affiliations
Panchumarthy Ravisankar, MD. Shaheem Sulthana, N. Sreenivasulu, D. Neelima Lakshmi, G. Lakshmi Priyanka, B. Pavan Kumar Reddy
Analytical method development and validation of simultaneous estimation of Metolazone and Spironolactone in bulk and pharmaceutical dosage form by RP-HPLC
This paper describes a novel, simple, precise, accurate, sensitive, rapid reversed-phase liquid chromatographic method for simultaneous estimation of Metolazone and Spironolactone in bulk and pharmaceutical dosage form...
FORMULATION AND EVALUATION OF DEXLANSOPRAZOLE DELAYED RELEASE CAPSULES
The present research work is formulation and evaluation of dexlansoprazole delayed release capsules. Dexlansoprazole is proton pump inhibitor (PPI) used in treatment of gastro esophageal reflux disease (G.E.R.D), Erosi...
TRANSDERMAL IONTOPHORESIS TECHNIQUE-A POTENTIAL EMERGING DRUG DELIVERY SYSTEM
The objective of delivery system is to achieve optimum therapeutic management. But, it still remains a challenge in the field of pharmaceuticals for delivery of ionic species such as proteins and peptides. Development...
A new development and validated RP-HPLC method for the assay and related substances of Itraconazole in capsule dosage form
The present investigation reveals about a simple, economic, selective, precise and accurate reverse phase high performance liquid chromatography method for analysis of Itraconazole and Related Substances of Itraconazol...
A study on Nanotechnology and its’ application in various fields
Nanotechnology means controlling or handling the matter of an atom, molecule or supra molecule. It can also be referred as molecular nanotechnology, where the atoms and molecules were precisely manipulated or controlle...