Diagnosis of non-alcoholic fatty liver disease (NAFLD) in overweight and obese women with polycystic ovary syndrome (PCOS). Metabolic associations between NAFLD and PCOS – preliminary study
Journal Title: Postępy Nauk Medycznych - Year 2014, Vol 27, Issue 12
Abstract
Introduction. Recent findings suggest that women with polycystic ovary syndrome (PCOS) may be at risk for developing non-alcoholic fatty liver disease (NAFLD) and conversely, hepatic steatosis may be a risk factor for PCOS.Aim. To estimate noninvasively the prevalence of non-alcoholic fatty liver disease in overweight and obese women with polycystic ovary syndrome and to investigate potential metabolic associations between NAFLD and PCOS.Material and methods. In 35 overweight and obese women with PCOS (19-49 years, BMI 26.8-60.2 kg/m2) aminotransferases activity was estimated and ultrasonography imaging was performed.Results. In 17 of all subjects (48.6%) NAFLD was diagnosed. ALT and GGTP were significantly higher, and de Ritis ratio (ATP/ALT) was lower in women with NAFLD in comparison to subjects without liver steatosis, and correlated with indices of obesity. In women with NAFLD glucose, insulin and HOMA were higher than in patients without liver disease. In NAFLD patients ALT and de Ritis ratio correlated with LDL-cholesterol. ALT and GGTP correlated also with triglyceride levels. LH/FSH ratio was lower in women with NAFLD in comparison to patients without liver steatosis.Conclusions. Non-alcoholic liver disease was diagnosed non-invasively in nearly half of overweight/obese subjects with PCOS. Non-invasive markers of liver diseases correlated with indices of obesity, glucose and lipid metabolism. Lower LH/FSH ratio in women with NAFLD may suggest, that abnormalities associated with liver steatosis additionally contribute to hormonal dysregulation in women with PCOS.
Authors and Affiliations
Jarosław Kozakowski, Renata Kapuścińska, Wojciech Zgliczyński
Keywords
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