Diagnostic Role of Immunohistochemistry in Mimics of Prostatic Adenocarcinoma
Journal Title: International Journal of Medical Research Professionals - Year 2018, Vol 4, Issue 1
Abstract
Objectives: To study and recognize different morphologic patterns of benign mimics of prostatic adenocarcinoma and couple it with use of immunohistochemistry for correct diagnosis and avoid false positive carcinoma interpretation. Materials and Methods: Prostatic biopsy specimens were evaluated by histopathology using haematoxylin and eosin (H/E) staining. In suspicious cases for malignant lesions, immunohistochemistry (IHC) analysis using basal cell markers p63 and HMWCK 34βE12 were performed to confirm the final diagnosis. Results: One hundred and ninety three prostatic biopsy specimens were received in department of pathology, 92(47.66%) were benign hyperplasia while carcinoma constituted 39(20.2%) cases. Among the remaining 62 specimens, 30 showed features of mimics while 32 specimens were suspicious of carcinoma. Of these 62 specimens, IHC analysis using basal cell markers like p63 and 34bE12 were performed. All the mimics were found negative of malignancy. But among 32 suspicious specimen of carcinoma, 8 cases were confirmed as prostate carcinoma while 24 cases were diagnosed as mimics of prostatic carcinoma. Conclusion: In morphologically equivocal glandular architectural patterns and cytological features, immunohistochemistry highlighting the basal cell mar
Authors and Affiliations
Gayatri Behera, Lity Mohanty, Sujata Pujari, Sambit Kumar Behera, Jyoti Ranjan Behera, Shushruta Mohanty
Keywords
Related Articles
- EP ID EP529099
- DOI 10.21276/ijmrp.2018.4.1.014
- Views 143
- Downloads 0
Immune Thrombocytopenia: An Exceptional Manifestation of Tuberculosis
Association of immune thrombocytopenic purpura and tuberculosis is an exceptional condition. We report a case of cervical & retroperitoneal lymph node tuberculosis who presented with ITP. A 17 year old male was admitted...
Elderly Versus Young Primi Gravida: A Clinical Analysis of Pregnancy Outcome in a Tertiary Care Hospital in Kashmir
Background: In obstetric practice, maternal age is an important determinant of outcome of pregnancy. One such risk factor is an elderly pregnancy that leads to many complications during pregnancy, labor and also for the...
Assessment of Alanine Aminotransferase (ALT) Level as a Risk Factor Among Chronic Hepatitis B Infection Patients: A Retrospective Analysis Over a Period of 20 Years
Introduction: Liver conditions such as liver cirrhosis and HCC are caused by CHB progression. ALT; is a marker of hepatocyte inflammation. Repeated periodic testing is recommended for liver evaluation. High results of AL...
Study of Zinc Level in Egyptian Cirrhotic Patients with Different Stages of Liver Cirrhosis
Background: Liver cirrhosis is a widespread disease differentiated by spread liver fibrosis and formation of nodules. During the last years, concentrations of minerals in patients with chronic hepatic disease have been i...
Assessment of Myocardial Perfusion Scan in the Detection of Ischemia and Accurately Measuring the Ejection Fraction in CAD Patients in Western Saudi Arabia: A Retrospective Cohort Study
Background: Cardiovascular diseases are one of the most common diseases in Saudi Arabia and one of the most common leading causes of death. Myocardial perfusion scan (MPI) is one of the most commonly used imaging techniq...