Diagnostic Role of Immunohistochemistry in Mimics of Prostatic Adenocarcinoma
Journal Title: International Journal of Medical Research Professionals - Year 2018, Vol 4, Issue 1
Abstract
Objectives: To study and recognize different morphologic patterns of benign mimics of prostatic adenocarcinoma and couple it with use of immunohistochemistry for correct diagnosis and avoid false positive carcinoma interpretation. Materials and Methods: Prostatic biopsy specimens were evaluated by histopathology using haematoxylin and eosin (H/E) staining. In suspicious cases for malignant lesions, immunohistochemistry (IHC) analysis using basal cell markers p63 and HMWCK 34βE12 were performed to confirm the final diagnosis. Results: One hundred and ninety three prostatic biopsy specimens were received in department of pathology, 92(47.66%) were benign hyperplasia while carcinoma constituted 39(20.2%) cases. Among the remaining 62 specimens, 30 showed features of mimics while 32 specimens were suspicious of carcinoma. Of these 62 specimens, IHC analysis using basal cell markers like p63 and 34bE12 were performed. All the mimics were found negative of malignancy. But among 32 suspicious specimen of carcinoma, 8 cases were confirmed as prostate carcinoma while 24 cases were diagnosed as mimics of prostatic carcinoma. Conclusion: In morphologically equivocal glandular architectural patterns and cytological features, immunohistochemistry highlighting the basal cell mar
Authors and Affiliations
Gayatri Behera, Lity Mohanty, Sujata Pujari, Sambit Kumar Behera, Jyoti Ranjan Behera, Shushruta Mohanty
Keywords
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- EP ID EP529099
- DOI 10.21276/ijmrp.2018.4.1.014
- Views 124
- Downloads 0
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