Do diabetes and nutrition status determine plasma magnesium concentration in patients on chronic renal replacement therapy?
Journal Title: Postępy Nauk Medycznych - Year 2015, Vol 28, Issue 10
Abstract
Introduction. Magnesium depletion negatively impacts the cardiovascular system, inflammation,insulin resistance and diabetes – in patients on chronic haemodialysis it islinked to worse prognosis and inflammation, and the magnesaemia correlates with proteinintake (nPCR) and creatininaemia.Aim. To verify which elements of the standard set of clinical data used for assessmentof nutrition status, correlate best with plasma magnesium in diabetic and non-diabeticpatients on chronic haemodialysis program.Material and methods. Single-unit observational study, based on standard laboratoryand clinical parameters obtained at the beginning of a single midweek haemodialysis sessionfor routine cyclic workup in patients on regular chronic haemodialysis.Results. Out of 147 adult patients on regular chronic haemodialysis (males 83, females64; median age 68 years) 57 had diabetes. Hypomagnesaemia was diagnosed in2 (1.19%), and hypermagnesaemia in 39 (23.21%). Serum magnaesium concentrationwas < 0.83 mmol/l in 32 patients (21.77%) – 16 with, and 16 without diabetes (28 and17.8% of all patients with and without diabetes, respectively). The only variables correlatingwith magnesaemia were nPCR, plasma creatinine and albumin (R2 = 0.32). Withineach tertile of magnesaemia, none of the predialysis blood parameters analysed differedin patients with diabetes from that in patients with no diabetes, with an exception for ureaand phosphate concentrations, higher in patients with diabetes within the tertile 2.Conclusions. Better diet results in better nutrition and higher magnesium serum concentrationin haemodialysis patients, which might prevent, or diminish inflammation also inpatient with diabetes. The efficacy of dialysis seemed of lesser importance.
Authors and Affiliations
Ryszard Gellert, Katarzyna Chmiel-Majewska, Tomasz Żelek, Dorota Daniewska
Keywords
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