Dynamics of clinical manifestations and blood serum content of specific cytokines in patients with rosacea treated by means of integrated therapy
Journal Title: Український журнал дерматології, венерології, косметології - Year 2018, Vol 0, Issue 3
Abstract
Objective — to determine and analyze the dynamics of clinical manifestations and blood serum content of specific cytokines in patients with rosacea treated by means of integrated therapy. Materials and methods. The study involved 110 patients with rosacea (71 women and 39 men), aged 29 to 64; 36 of them were diagnosed with erythematous-telangiectatic and 74 — with papulo-pustular stage (form) of rosacea. In the course of treatment the patients with rosacea were divided into 2 groups: group І (comparative) consisted of 56 patients who received a standard treatment, group ІІ (main) included 54 patients, who were additionally administered an antioxidant ethylmethylhydroxypyridine succinate, antihistamines and anti-inflammatory drugs (bilastin, ketotifen fumarate). In patients with rosacea, the blood serum content of certain cytokines — interleukins 4, 8, 10, 17А, 18 (IL-4, IL-8, IL-10, IL-17A, IL-18) was measured before and after treatment by the method of immunoassay analysis as well as the dynamics of clinical manifestations of dermatosis on the scale of the diagnostic evaluation of rosacea (SDER) was evaluated. Results and discussion. Before the treatment the patients with rosacea in both main and comparative groups had a reliable (р < 0.05), compared to the values in the control group, increase in the blood serum of inflammatory cytokines ІL-8 (by 2.2 and 2.1 times, respectively), ІL-17А (by 4.0 and 4.3 times) and ІL-18 (by 1.7 and 1.6 times) without significant changes in the level of anti-inflammatory cytokines IL-4 and IL-10. The patients of the main group after integrated treatment had a decrease in the blood serum of ІL-8 (by 1.8 times, р = 0.036), ІL-17А (by 1.9 times, р = 0.006) and ІL-18 (by 27.5 %, р = 0.075). At the same time there was a tendency towards a decrease in patients of the comparative group of IL-18 (by 22.7 %, p = 0.15). Patients in the main group also had better clinical results after the complex treatment with a reliable reduction in SDER (by 1.7 times, р < 0.001) compared to the comparative group. Conclusions. It has been established that the use in the complex treatment of patients with rosacea of antioxidant ethylmethylhydroxypyridine succinate and antihistamines with anti-inflammatory action (bilastin, ketotifen fumarate) contributes to the normalization or trends towards to the normalization of serum content of proinflammatory cytokines (IL-8, IL-17A, IL-18), as well as significantly improves the clinical outcomes of the treatment of such patients.
Authors and Affiliations
M. V. Storozhuk, O. I. Denysenko
Keywords
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- EP ID EP420465
- DOI 10.30978/UJDVK2018-3-22
- Views 92
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