Effect of Aloe vera gel on lipid profile and some serum biomarkers of liver function in high salt fed Wistar rats
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2018, Vol 13, Issue 5
Abstract
This study examined the effect of Aloe vera gel on lipid profile and some serum biomarkers of liver function in high salt-fed wistar rats. Twenty male wistar rats (200-250g) were randomly assigned into four groups (n=5): 1 (control) received rat feed and water; 2 (ALOE) received 600mg/kg of Aloe vera orally once daily; 3 (SALT) received high salt diet (8% NaCl feed + 1% NaCl drinking water); 4 (SALT+ALOE) received high salt diet + Aloe vera. The feeding regimen lasted for six weeks after which blood samples were collected for analysis. Total protein and globulin concentration was significantly (p<0.001) increased in ALOE and SALT groups compared with control. AST, ALT and ASP were significantly (p<0.001) increased in ALOE and SALT+ALOE groups compared with control. Total and conjugated bilirubin concentration was significantly (p<0.001) increased in SALT and SALT+ALOE compared with control and ALOE. Unconjugated bilirubin concentration was significantly decreased in SALT compared with control (p<0.01) and ALOE (p<0.001). MDA was significantly (p<0.05) decreased in SALT+ALOE compared with SALT. TC and LDL-c were significantly decreased in SALT+ALOE compared with SALT. Aloe vera gel therefore exhibited hepatoprotective effect and has the potential to treat hyperlipidaemia and hyperbilirubinaemia associated with high salt intake.
Authors and Affiliations
Clement O. Nku, Archibong N. Archibong, Augustine L. Udefa, Paul L. Utionkpan, Ada A. Akwari
Keywords
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- EP ID EP415679
- DOI 10.9790/3008-1305045061.
- Views 66
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