EFFECT OF GNRH ANTAGONISTS ON CLINICAL PREGNANCY RATES IN CONTROLLED OVARIAN STIMULATION AND INTRAUTERINE INSEMINATION
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 55
Abstract
BACKGROUND Controlled Ovarian Stimulation (COS) with Intrauterine Insemination (IUI) is widely used in the treatment of unexplained infertility, mild and moderate endometriosis or male factor infertility to achieve a higher pregnancy rate. Several studies have reported conflicting results regarding the outcome of COS-IUI cycles using GnRH antagonists in terms of clinical pregnancy rate. The aim of the study is to study whether use of GnRH antagonist in IUI cycles where HMG was used for ovulation induction improved clinical pregnancy rates. MATERIALS AND METHODS This was a prospective randomised controlled trial study of 316 couples conducted at Ray Hospital and Test Tube Baby Centre from October 2013 to September 2015. The patients in group A received HMG and GnRH antagonist for COH, while those in group B received only HMG. Clinical pregnancy rates were compared. Study Design- Randomised Controlled Trial. Statistical Analysis- Statistical analyses were performed using the SPSS version 17.0 program (SPSS Inc., Chicago, IL, USA) for Windows. Student’s t-test was used for comparing continuous variables that showed normal distribution, while Mann-Whitney U test was used for variables that did not follow a normal distribution. RESULTS Clinical pregnancy rate was 15.6% in GnRH antagonist group and 13.6% in the control group (P = 0.78). CONCLUSION The present study revealed no significant difference when GnRH antagonist is added to gonadotropin-stimulated IUI cycles in terms of clinical pregnancy rate.
Authors and Affiliations
Rajat Kumar Ray, Sunita Samal
Keywords
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- EP ID EP225895
- DOI 10.14260/Jemds/2017/899
- Views 91
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