Effect of Isotretinoin on Mood Status and Psychological Changes Among Female Saudi Patients Between Twenty and Twenty Five Years Old, Diagnosed with Acne Vulgaris in Makkah, 2013
Journal Title: International Journal of Medical Research Professionals - Year 2018, Vol 4, Issue 4
Abstract
Introduction: Isotretinoin (trade names Roaccutane and Oratane) is a vitamin A derivative. It has been approved for the treatment for nodular and cystic acne and there is an association between the drug and mood and psychological disturbance. Methodology: A cross sectional study was done among a random sample of seventy Saudi female patients. Their ages ranged from twenty to twenty five year old. Their body weight ranged from 50 to 65 kg. All of them were previously healthy, no history of psychotic disorders or medications, and no family history of psychotic problem. They were diagnosed with Severe Acne vulgaris. The questioners were distributed among them and additionally, verbal filling of some questioners were done. Results: Fifty-seven (81.4) cases developed rapid changing mood after taking the drug, 31( 44.2%) cases noticed sudden boots of crying with no reason, 39 (55.7% ) cases become anxious, 52 (74.2%) cases start feeling depressed after the drug taking, 17 (24.2%) cases noticed new onset sleep disturbance, 6 (8.5 %) cases recorded that the drug has negative effect on education and learning, 2 (2.8%) cases sought medical help for antidepressant medications, and one (1.4%) case had thinking of suicide idea but no cases attempt to suicide after the drug. Conclusion: Isotretinoin has an observational subjective negative effect on mood and psychological state of a normal health individual. These effects correlated with the duration of the drug taking.
Authors and Affiliations
Ahmed Alliali, Tahani Magliah, Salwa Bardisi, Safa Magliah, Dania Magliah
Keywords
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- EP ID EP534270
- DOI 10.21276/ijmrp.2018.4.4.018
- Views 62
- Downloads 0
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