EFFECT OF METHANOLIC EXTRACT OF SWEET CORN SILK ON EXPERIMENTALLY INDUCED HYPERTHYROIDISM IN SWISS ALBINO RATS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 3
Abstract
Plant materials have been used as medicine for a wide variety of human ailments due to increase in cost of treatment, side effects of several allopathic drugs and development of resistance to currently used drugs for infectious diseases. In the present study, hyperthyroidism was induced to male Swiss albino rats orally using thyroxine for 14 days. The impact of methanolic extract of sweet corn silk in different concentrations (200, 300 & 400mg/kg) for 21 days was assessed in these animals. The serum was analyzed for thyroid hormone level and lipid profile before and during the experiment. Results showed that 400mg/kg concentration of methanolic extract has the highest effectiveness which is equal to that of standard drug to revert the hyperthyroid condition in Swiss albino rats and were confirmed with the histopathological study of the thyroid gland.
Authors and Affiliations
Bhaigyabati Thoudam , J Ramya , K. Usha
Keywords
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